CAPN10 | ENSG00000142330 | NCBI 11132

Details for: CAPN10

Gene ID: 11132

Symbol: CAPN10

Ensembl ID: ENSG00000142330

Description: calpain 10

Associated with

Degradation of the extracellular matrix
(R-HSA-1474228)
Extracellular matrix organization
(R-HSA-1474244)
Calcium-dependent cysteine-type endopeptidase activity
(GO:0004198)
Cellular component disassembly involved in execution phase of apoptosis
(GO:0006921)
Cellular response to insulin stimulus
(GO:0032869)
Cytoplasm
(GO:0005737)
Cytoskeletal protein binding
(GO:0008092)
Cytosol
(GO:0005829)
Mitochondrion
(GO:0005739)
Plasma membrane
(GO:0005886)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of intracellular transport
(GO:0032388)
Positive regulation of type b pancreatic cell apoptotic process
(GO:2000676)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Regulation of actin cytoskeleton organization
(GO:0032956)
Snare binding
(GO:0000149)
Type b pancreatic cell apoptotic process
(GO:0097050)

Other Information

Proteins

Calpain-10

Genular Protein ID: 515550804

Symbol: CAN10_HUMAN

Name: Calpain-10

UniProtKB Accession Codes:

Q9HC96 A8MVS7 Q4ZFV1 Q8NCD4 Q96IG4 Q96JI2 Q9HC89 Q9HC90 Q9HC91 Q9HC92 Q9HC93 Q9HC94 Q9HC95

Database IDs:

Citations:

PubMed ID: 11017071

Title: Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.

PubMed ID: 11017071

DOI: 10.1038/79876

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 16721485

Title: A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes.

PubMed ID: 16721485

DOI: 10.1007/s10038-006-0410-9

PubMed ID: 17572128

Title: Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells.

PubMed ID: 17572128

DOI: 10.1016/j.ymgme.2007.05.001

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 672
Mass: 74952
Checksum: 74A48D879E896C71
Sequence:

MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP 
REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV 
EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKVYAKVHG SYEHLWAGQV ADALVDLTGG 
LAERWNLKGV AGSGGQQDRP GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF 
IVSDLRELQG QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE 
FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ SAGGCRNNSG 
FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV GDSHTSWSPA SIPGKHYQAV 
GLHLWKVEKR RVNLPRVLSM PPVAGTACHA YDREVHLRCE LSPGYYLAVP STFLKDAPGE 
FLLRVFSTGR VSLSAIRAVA KNTTPGAALP AGEWGTVQLR GSWRVGQTAG GSRNFASYPT 
NPCFPFSVPE GPGPRCVRIT LHQHCRPSDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL 
LSCVPHRYAQ EVSRLCLLPA GTYKVVPSTY LPDTEGAFTV TIATRIDRPS IHSQEMLGQF 
LQEVSIMAVM KT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CAPN10

Associated with

Other Information

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. PubMed ID: 11017071

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 11347906

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An unappreciated role for RNA surveillance. PubMed ID: 14759258

A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes. PubMed ID: 16721485

Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells. PubMed ID: 17572128

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974