Details for: CSPG4P1Y

Gene ID: 114758

Symbol: CSPG4P1Y

Ensembl ID: ENSG00000240450

Description: CSPG4 pseudogene 1 Y-linked

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0071
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0036
    Cell Significance Index: -0.0300
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0059
    Cell Significance Index: -0.0500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0063
    Cell Significance Index: -0.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Y-linked pseudogene:** CSPG4P1Y is a pseudogene located on the Y chromosome, which is a vestigial remnant of a gene that has undergone pseudogenization. 2. **Widespread expression:** CSPG4P1Y is expressed in various cell types, including intestinal enteroendocrine cells, brush cells, and epithelial cells, highlighting its potential role in tissue homeostasis and development. 3. **Intestinal tissue specificity:** CSPG4P1Y is significantly expressed in intestinal tissues, particularly in cells involved in absorption, secretion, and immune function. **Pathways and Functions:** 1. **Intestinal epithelial cell development:** CSPG4P1Y may play a role in the development and differentiation of intestinal epithelial cells, particularly in the context of intestinal stem cell self-renewal and differentiation. 2. **Neuroendocrine signaling:** CSPG4P1Y may be involved in neuroendocrine signaling pathways, influencing the secretion of hormones and neurotransmitters in enteroendocrine cells. 3. **Immune cell modulation:** CSPG4P1Y may also modulate immune cell function, particularly in the context of intestinal inflammation and immune tolerance. **Clinical Significance:** 1. **Intestinal diseases:** CSPG4P1Y dysregulation may contribute to the development of intestinal diseases, such as inflammatory bowel disease (IBD), celiac disease, and cancer. 2. **Neurological disorders:** CSPG4P1Y may also play a role in neurological disorders, such as Parkinson's disease and Alzheimer's disease, where intestinal epithelial cells and neuroendocrine cells interact. 3. **Cancer research:** CSPG4P1Y may serve as a potential biomarker for cancer diagnosis and prognosis, particularly in the context of colon cancer and other gastrointestinal malignancies. In conclusion, CSPG4P1Y is a complex and multifunctional gene that has shed light on the intricate relationships between intestinal tissues, immune cells, and neurological systems. Further research is needed to fully elucidate the mechanisms underlying CSPG4P1Y's functions and to explore its potential as a therapeutic target for intestinal and neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.