AMACR | ENSG00000242110 | NCBI 23600

Details for: AMACR

Gene ID: 23600

Symbol: AMACR

Ensembl ID: ENSG00000242110

Description: alpha-methylacyl-CoA racemase

Associated with

Beta-oxidation of pristanoyl-coa
(R-HSA-389887)
Bile acid and bile salt metabolism
(R-HSA-194068)
Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Peroxisomal lipid metabolism
(R-HSA-390918)
Peroxisomal protein import
(R-HSA-9033241)
Protein localization
(R-HSA-9609507)
Synthesis of bile acids and bile salts
(R-HSA-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-HSA-193368)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(R-HSA-193775)
Alpha-methylacyl-coa racemase activity
(GO:0008111)
Bile acid biosynthetic process
(GO:0006699)
Bile acid metabolic process
(GO:0008206)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Fatty acid beta-oxidation using acyl-coa oxidase
(GO:0033540)
Intracellular membrane-bounded organelle
(GO:0043231)
Mitochondrion
(GO:0005739)
Peroxisomal matrix
(GO:0005782)
Peroxisome
(GO:0005777)
Plasma membrane
(GO:0005886)

Other Information

Proteins

Alpha-methylacyl-CoA racemase

Genular Protein ID: 1235075945

Symbol: AMACR_HUMAN

Name: Alpha-methylacyl-CoA racemase

UniProtKB Accession Codes:

Q9UHK6 A5YM47 B8Y916 B8Y918 F8W9N1 O43673 Q3KT79 Q96GH1 Q9Y3Q1

Database IDs:

Citations:

PubMed ID: 11060344

Title: Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans.

PubMed ID: 11060344

PubMed ID: 10655068

Title: Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy.

PubMed ID: 10655068

DOI: 10.1038/72861

PubMed ID: 15880524

Title: A variant of the alpha-methyl-acyl-CoA racemase gene created by a deletion in exon 5 and its expression in prostate cancer.

PubMed ID: 15880524

DOI: 10.1002/pros.20277

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7649182

Title: Purification and characterization of an alpha-methylacyl-CoA racemase from human liver.

PubMed ID: 7649182

DOI: 10.1111/j.1432-1033.1995.tb20766.x

PubMed ID: 11060359

Title: Subcellular localization and physiological role of alpha-methylacyl-CoA racemase.

PubMed ID: 11060359

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12512044

Title: Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy.

PubMed ID: 12512044

DOI: 10.1053/gast.2003.50017

Sequence Information:

Length: 382
Mass: 42387
Checksum: E967D3221A90BEF8
Sequence:

MALQGISVVE LSGLAPGPFC AMVLADFGAR VVRVDRPGSR YDVSRLGRGK RSLVLDLKQP 
RGAAVLRRLC KRSDVLLEPF RRGVMEKLQL GPEILQRENP RLIYARLSGF GQSGSFCRLA 
GHDINYLALS GVLSKIGRSG ENPYAPLNLL ADFAGGGLMC ALGIIMALFD RTRTGKGQVI 
DANMVEGTAY LSSFLWKTQK LSLWEAPRGQ NMLDGGAPFY TTYRTADGEF MAVGAIEPQF 
YELLIKGLGL KSDELPNQMS MDDWPEMKKK FADVFAEKTK AEWCQIFDGT DACVTPVLTF 
EEVVHHDHNK ERGSFITSEE QDVSPRPAPL LLNTPAIPSF KRDPFIGEHT EEILEEFGFS 
REEIYQLNSD KIIESNKVKA SL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AMACR

Associated with

Other Information

Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans. PubMed ID: 11060344

Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy. PubMed ID: 10655068

A variant of the alpha-methyl-acyl-CoA racemase gene created by a deletion in exon 5 and its expression in prostate cancer. PubMed ID: 15880524

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of an alpha-methylacyl-CoA racemase from human liver. PubMed ID: 7649182

Subcellular localization and physiological role of alpha-methylacyl-CoA racemase. PubMed ID: 11060359

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy. PubMed ID: 12512044