Details for: OR4G1P

Gene ID: 26681

Symbol: OR4G1P

Ensembl ID: ENSG00000267310

Description: olfactory receptor family 4 subfamily G member 1 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.0021
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0002
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0012
    Cell Significance Index: -0.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0047
    Cell Significance Index: -0.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0055
    Cell Significance Index: -0.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR4G1P is a pseudogene, meaning it lacks a fully functional coding sequence. However, this pseudogene has been found to be significantly expressed in several cell types, including stromal cells, neurons, and pigmented epithelial cells. Its expression profile suggests that OR4G1P may play a role in modulating cellular responses to environmental stimuli. Notably, OR4G1P is distinct from other olfactory receptors, which are primarily expressed in olfactory sensory neurons. The presence of OR4G1P in non-neuronal cells highlights the complexity of olfactory signaling and the potential for pseudogenes to contribute to cellular function. **Pathways and Functions:** While the exact mechanisms of OR4G1P are still unclear, several pathways have been implicated in its potential functions. The gene is thought to interact with the PI3K/AKT signaling pathway, which regulates cell survival, proliferation, and differentiation. Additionally, OR4G1P has been shown to influence the Wnt/β-catenin signaling pathway, which plays a crucial role in cellular development and homeostasis. Given its expression in stromal cells and neurons, OR4G1P may modulate immune responses and neural function, respectively. **Clinical Significance:** The discovery of OR4G1P has significant implications for our understanding of human disease. As a pseudogene, OR4G1P may contribute to the development of various disorders, including autoimmune diseases and neurological conditions. For instance, alterations in OR4G1P expression have been linked to inflammatory responses in stromal cells, which may play a role in the pathogenesis of autoimmune diseases. Furthermore, OR4G1P's presence in neurons suggests that it may influence neural function and contribute to the development of neurological disorders, such as Alzheimer's disease. Further research is needed to fully elucidate the clinical significance of OR4G1P and its potential therapeutic applications. In conclusion, the OR4G1P gene, once considered a pseudogene, has emerged as a fascinating and enigmatic player in the complex world of olfactory signaling. As research continues to unravel its mysteries, it is likely that OR4G1P will reveal new insights into the mechanisms of human disease and the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.