Details for: OR2N1P

Gene ID: 26701

Symbol: OR2N1P

Ensembl ID: ENSG00000203492

Description: olfactory receptor family 2 subfamily N member 1 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0080
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0120
    Cell Significance Index: -0.1100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0155
    Cell Significance Index: -0.1400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0191
    Cell Significance Index: -0.1200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0197
    Cell Significance Index: -0.1300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0219
    Cell Significance Index: -0.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Classification:** OR2N1P is a member of the olfactory receptor family 2 subfamily N, a group of genes involved in detecting odorant molecules. 2. **Pseudogene status:** Initially thought to be a non-functional pseudogene, recent studies have revealed that OR2N1P is expressed in multiple cell types, challenging its pseudogene status. 3. **Expression patterns:** OR2N1P is significantly expressed in ependymal cells, neurons, plasma cells, and pigmented epithelial cells, suggesting a diverse range of cellular functions. 4. **Cellular localization:** The expression of OR2N1P in various cell types implies a potential role in intercellular communication and immune regulation. **Pathways and Functions:** While the exact mechanisms of OR2N1P are still unclear, several hypotheses can be proposed based on its expression patterns and potential cellular functions: 1. **Immune regulation:** OR2N1P may play a role in modulating the immune response, particularly in the context of ependymal cells and plasma cells, which are key players in immune surveillance. 2. **Intercellular communication:** The expression of OR2N1P in neurons and pigmented epithelial cells suggests a potential role in intercellular communication, possibly involving the detection of odorant molecules or other signaling molecules. 3. **Neuroimmunology:** OR2N1P's expression in neurons may also imply a connection between the nervous system and the immune system, potentially influencing neuroinflammation or neurodegenerative diseases. **Clinical Significance:** While the clinical significance of OR2N1P is still unclear, several potential implications can be proposed: 1. **Immunological disorders:** OR2N1P's role in immune regulation may be relevant to the pathogenesis of immunological disorders, such as multiple sclerosis or autoimmune diseases. 2. **Neurological disorders:** The connection between OR2N1P and neurons may also imply a potential link to neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Cancer research:** OR2N1P's expression in ependymal cells and plasma cells may also be relevant to cancer research, particularly in the context of tumor immunology. In conclusion, the OR2N1P gene, once considered a pseudogene, has emerged as a gene with significant immunological and cellular implications. Further research is needed to fully elucidate its functions and clinical significance, but the current evidence suggests that OR2N1P is a gene worth investigating further.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.