Details for: SNORD61

Gene ID: 26787

Symbol: SNORD61

Ensembl ID: ENSG00000206979

Description: small nucleolar RNA, C/D box 61

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0142
    Cell Significance Index: 0.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0112
    Cell Significance Index: 0.1300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0066
    Cell Significance Index: 0.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0036
    Cell Significance Index: -0.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0098
    Cell Significance Index: -0.1100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0186
    Cell Significance Index: -0.2300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0213
    Cell Significance Index: -0.2800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0219
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0241
    Cell Significance Index: -0.2600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0271
    Cell Significance Index: -0.3100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0283
    Cell Significance Index: -0.3200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0284
    Cell Significance Index: -0.3500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0289
    Cell Significance Index: -0.3100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0290
    Cell Significance Index: -0.3600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0324
    Cell Significance Index: -0.2700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0366
    Cell Significance Index: -0.2800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0406
    Cell Significance Index: -0.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD61 is a small nucleolar RNA, specifically a C/D box snoRNA, which is characterized by its unique secondary structure and the presence of specific nucleotides. C/D box snoRNAs are known to interact with proteins involved in ribosome biogenesis, such as Nop1p and Nop2p, to regulate the processing of ribosomal RNA (rRNA) and the assembly of ribosomes. SNORD61 is significantly expressed in various cell types, including pericytes, cardiac endothelial cells, immature innate lymphoid cells, cardiac muscle myoblasts, lymphoid lineage-restricted progenitor cells, fibroblasts of cardiac tissue, smooth muscle myoblasts, type A enteroendocrine cells, neuronal receptor cells, and retina horizontal cells. **Pathways and Functions:** SNORD61 is involved in several key pathways, including: 1. **Ribosome Biogenesis**: SNORD61 interacts with Nop1p and Nop2p to regulate the processing of rRNA and the assembly of ribosomes. This process is essential for protein synthesis and cell growth. 2. **RNA Processing**: SNORD61 is involved in the regulation of RNA processing, including the maturation of rRNA and the formation of ribonucleoprotein complexes. 3. **Cellular Differentiation**: SNORD61 expression is altered in various cell types, suggesting its involvement in cellular differentiation and development. 4. **Apoptosis**: SNORD61 has been shown to regulate apoptosis in certain cell types, suggesting its role in maintaining cellular homeostasis. **Clinical Significance:** The clinical significance of SNORD61 is an area of ongoing research. However, studies have shown that alterations in SNORD61 expression are associated with various diseases, including: 1. **Cardiovascular Diseases**: SNORD61 expression is altered in cardiac tissue, suggesting its role in the development of cardiovascular diseases. 2. **Cancer**: SNORD61 expression is altered in various types of cancer, including leukemia and lymphoma. 3. **Neurological Disorders**: SNORD61 expression is altered in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, SNORD61 is a small nucleolar RNA that plays a crucial role in ribosome biogenesis, RNA processing, cellular differentiation, and apoptosis. Its widespread expression in various cell types suggests its involvement in various diseases, including cardiovascular diseases, cancer, and neurological disorders. Further research is needed to fully understand the role of SNORD61 in human health and disease. **Recommendations:** 1. **Further Research**: Additional studies are needed to elucidate the mechanisms by which SNORD61 regulates ribosome biogenesis, RNA processing, cellular differentiation, and apoptosis. 2. **Clinical Application**: SNORD61 may have potential as a therapeutic target for the treatment of cardiovascular diseases, cancer, and neurological disorders. 3. **Diagnostic Biomarker**: SNORD61 may serve as a diagnostic biomarker for various diseases, including cardiovascular diseases and cancer. By continuing to explore the role of SNORD61 in human health and disease, we may uncover new insights into the mechanisms of various diseases and develop novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.