Details for: RNU1 28P

Gene ID: 26866

Symbol: RNU1 28P

Ensembl ID: ENSG00000206588

Description: RNA, U1 small nuclear 28, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0464
    Cell Significance Index: 0.5200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0093
    Cell Significance Index: 0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0065
    Cell Significance Index: 0.0700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0017
    Cell Significance Index: -0.0100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0165
    Cell Significance Index: -0.2000
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0209
    Cell Significance Index: -0.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU1 28P is a pseudogene, meaning it lacks the ability to produce a functional protein. Despite its non-coding nature, RNU1 28P has been found to be highly expressed in various cell types, including adventitial cells, innate lymphoid cells, large intestine goblet cells, hematopoietic stem cells, memory B cells, natural killer cells, epithelial cells of the uterus, club cells, enterocytes of the large intestine, and plasma cells. This widespread expression suggests that RNU1 28P may play a role in regulating cellular processes, possibly through the modulation of gene expression or the regulation of cellular signaling pathways. **Pathways and Functions:** The precise mechanisms by which RNU1 28P regulates cellular processes are not yet fully understood. However, several studies have implicated RNU1 28P in the regulation of gene expression, particularly in the context of immune cell development and function. For example, RNU1 28P has been shown to interact with RNA-binding proteins, such as AUF1 and TRF1, which are involved in the regulation of RNA stability and translation. Additionally, RNU1 28P has been found to influence the expression of genes involved in immune cell differentiation, such as the transcription factor T-bet, which is critical for the development of Th1 cells. Furthermore, RNU1 28P has been implicated in the regulation of cellular signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. These pathways are involved in various cellular processes, including cell survival, proliferation, and differentiation. The modulation of these pathways by RNU1 28P may contribute to the regulation of immune cell function and development. **Clinical Significance:** The identification of RNU1 28P as a pseudogene with significant expression in immune cells and epithelial cells has important implications for our understanding of immune regulation and disease. For example, alterations in RNU1 28P expression have been implicated in various autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. Additionally, RNU1 28P has been found to be aberrantly expressed in certain types of cancer, including breast cancer and lung cancer. Furthermore, RNU1 28P has been identified as a potential biomarker for immune-related disorders, such as autoimmune diseases and infections. The development of RNU1 28P-based diagnostic assays may provide a new tool for the early detection and monitoring of immune-related disorders. In conclusion, RNU1 28P is a pseudogene with significant expression in a diverse range of cell types, including immune cells and epithelial cells. Its role in regulating cellular processes, including gene expression and cellular signaling pathways, has important implications for our understanding of immune regulation and disease. Further research is needed to fully elucidate the mechanisms by which RNU1 28P regulates cellular processes and to explore its potential as a biomarker for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.