Details for: IGHV3 76

Gene ID: 28406

Symbol: IGHV3 76

Ensembl ID: ENSG00000253247

Description: immunoglobulin heavy variable 3-76 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0621
    Cell Significance Index: 0.7200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0273
    Cell Significance Index: 0.2900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0015
    Cell Significance Index: -0.0100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0153
    Cell Significance Index: -0.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0177
    Cell Significance Index: -0.2100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0283
    Cell Significance Index: -0.3600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0296
    Cell Significance Index: -0.2700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0329
    Cell Significance Index: -0.3700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0379
    Cell Significance Index: -0.4200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0453
    Cell Significance Index: -0.5500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0460
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0470
    Cell Significance Index: -0.4800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0495
    Cell Significance Index: -0.5100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0597
    Cell Significance Index: -0.5600
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0632
    Cell Significance Index: -0.6800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0634
    Cell Significance Index: -0.5800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0665
    Cell Significance Index: -0.6200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0720
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0854
    Cell Significance Index: -0.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3-76 gene is a member of the immunoglobulin heavy chain variable region 3 family, which is crucial for the development and function of B cells. As a pseudogene, it lacks the typical coding potential for protein synthesis, suggesting that its primary function may lie in regulating gene expression or modulating immune responses. The significantly expressed cells associated with this gene, including B cells, plasma cells, and stromal cells, underscore its importance in maintaining immune homeostasis. **Pathways and Functions:** Several pathways and mechanisms have been implicated in the regulation of IGHV3-76 gene expression, including: 1. **Epigenetic regulation:** DNA methylation and histone modification play crucial roles in silencing or activating IGHV3-76 gene expression, thereby modulating immune responses. 2. **Non-coding RNA (ncRNA) mediated regulation:** ncRNAs, such as microRNAs and long non-coding RNAs, may interact with IGHV3-76 gene regulatory elements to fine-tune its expression. 3. **Transcriptional regulation:** Transcription factors, such as AP-1 and NF-κB, have been shown to regulate IGHV3-76 gene expression in response to various stimuli. The functional significance of IGHV3-76 gene expression is multifaceted, including: 1. **Immune tolerance:** IGHV3-76 gene expression may contribute to immune tolerance by regulating the expression of immune suppressive genes. 2. **Autoimmune disease:** Dysregulation of IGHV3-76 gene expression has been implicated in various autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer immunology:** IGHV3-76 gene expression has been associated with cancer progression and immune evasion. **Clinical Significance:** The clinical significance of IGHV3-76 gene expression is an area of ongoing research, with potential implications for: 1. **Immunotherapy:** Understanding the molecular mechanisms underlying IGHV3-76 gene expression may provide insights into the development of novel immunotherapeutic strategies. 2. **Autoimmune disease diagnosis:** Biomarkers associated with IGHV3-76 gene expression may aid in the diagnosis and monitoring of autoimmune diseases. 3. **Cancer immunology:** IGHV3-76 gene expression may serve as a biomarker for cancer progression and immune evasion, guiding the development of targeted therapies. In conclusion, the IGHV3-76 gene, a pseudogene with broad functional implications, warrants further investigation into its molecular mechanisms and clinical significance. Elucidating the intricacies of this gene may lead to novel therapeutic strategies and a deeper understanding of the complex interplay between the immune system and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.