Details for: IGHD3 9

Gene ID: 28500

Symbol: IGHD3 9

Ensembl ID: ENSG00000211924

Description: immunoglobulin heavy diversity 3-9

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.76
    Marker Score: 1,162
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.49
    Marker Score: 259
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.28
    Marker Score: 158
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.18
    Marker Score: 136
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.12
    Marker Score: 65
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1
    Marker Score: 136
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 54
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 31

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHD3 is a member of the immunoglobulin heavy chain (IgH) gene family, which is responsible for encoding the heavy chains of antibodies. This gene is specifically designated as "diversity 3-9," indicating its involvement in the generation of diverse heavy chain repertoires. IGHD3 is expressed in a wide range of cells, including precursor B cells, hematopoietic stem cells, erythrocytes, early T lineage precursors, plasmacytoid dendritic cells, double negative thymocytes, mast cells, megakaryocytes, megakaryocyte-erythroid progenitor cells, and unswitched memory B cells. This widespread expression underscores the gene's importance in the development and maintenance of the immune system. **Pathways and Functions:** IGHD3 is involved in the process of somatic recombination, which is the mechanism by which the immune system generates a diverse repertoire of antibodies. This process involves the rearrangement of V(D)J recombination complexes, allowing for the creation of unique antibody heavy chains. IGHD3 contributes to this process by providing the necessary diversity elements, such as D and J segments, which are incorporated into the heavy chain variable region. The gene's products also participate in the regulation of gene expression, influencing the activation and proliferation of immune cells. Furthermore, IGHD3 has been implicated in the development of immunological tolerance, particularly in the context of T cell development. The gene's expression in double negative thymocytes, a stage of T cell development, suggests its involvement in the selection of self-reactive T cells, which is a critical process for maintaining immune homeostasis. **Clinical Significance:** Dysregulation of IGHD3 has been linked to various immunological disorders, including autoimmune diseases and immunodeficiencies. For instance, mutations in the IGHD3 gene have been associated with X-linked agammaglobulinemia (XLA), a condition characterized by the absence of mature B cells and reduced antibody production. Additionally, IGHD3 has been implicated in the pathogenesis of autoimmune diseases such as rheumatoid arthritis and lupus, where aberrant immune responses and dysregulated gene expression contribute to disease progression. In conclusion, IGHD3 is a gene of ongoing significance in the immune system, with far-reaching implications for our understanding of immune development, function, and disease. Further research is necessary to fully elucidate the mechanisms by which IGHD3 regulates immune cell development and function, as well as its role in the pathogenesis of immunological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.