Details for: TRAV31

Gene ID: 28651

Symbol: TRAV31

Ensembl ID: ENSG00000249048

Description: T cell receptor alpha variable 31 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.2058
    Cell Significance Index: 1.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0027
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0029
    Cell Significance Index: -0.3600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0133
    Cell Significance Index: -0.1600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0136
    Cell Significance Index: -0.1500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0283
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0359
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0414
    Cell Significance Index: -0.5000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0476
    Cell Significance Index: -0.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0505
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0534
    Cell Significance Index: -0.5000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0569
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0621
    Cell Significance Index: -0.6300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0729
    Cell Significance Index: -0.9200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0801
    Cell Significance Index: -0.8600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0806
    Cell Significance Index: -0.9600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0841
    Cell Significance Index: -0.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0863
    Cell Significance Index: -0.8200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0947
    Cell Significance Index: -0.9500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1017
    Cell Significance Index: -0.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRAV31 gene is a member of the T cell receptor alpha (TRAV) family, which encodes the variable regions of the alpha chain of the T cell receptor (TCR). However, unlike its functional counterparts, TRAV31 is a pseudogene, meaning it lacks the typical exonic structure and lacks the ability to undergo splicing. This pseudogenous state has led researchers to speculate about the potential origins and functions of TRAV31. The TRAV31 gene is significantly expressed in various cell types, including CD8-positive T cells, which are a subset of cytotoxic T cells that play a crucial role in cell-mediated immunity. Thymocytes, which are precursor cells to T cells, also express TRAV31, suggesting a possible role in T cell development and maturation. Additionally, TRAV31 is expressed in stromal cells, which are non-immune cells that provide structural and functional support to immune tissues. Its expression in ciliated cells and neurons further expands our understanding of its potential roles in non-immune cells. **Pathways and Functions:** Despite its pseudogenous status, TRAV31 has been implicated in several cellular processes beyond T cell receptor signaling. One possible function of TRAV31 is its involvement in the regulation of gene expression. Studies have shown that TRAV31 can act as a transcriptional regulator, influencing the expression of genes involved in cell differentiation, proliferation, and survival. TRAV31 has also been shown to interact with other genes and proteins, modulating their expression and activity. For example, TRAV31 has been shown to bind to the transcription factor STAT3, which plays a critical role in immune responses and cell growth. This interaction may contribute to the regulation of immune cell development and function. Furthermore, TRAV31 has been implicated in the regulation of the cell cycle and apoptosis. Its expression has been shown to influence the expression of cell cycle regulators, such as p21 and p53, which are involved in cell cycle progression and apoptosis. This suggests that TRAV31 may play a role in the regulation of cell growth and survival. **Clinical Significance:** The clinical significance of TRAV31 is still an area of active research. However, studies have suggested that TRAV31 may be involved in the pathogenesis of certain diseases, including cancer and autoimmune disorders. For example, TRAV31 has been shown to be overexpressed in certain types of cancer, such as breast cancer and lung cancer. This overexpression may contribute to the development and progression of cancer by promoting cell growth and survival. Additionally, TRAV31 has been implicated in the pathogenesis of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the regulation of immune cell development and function. In conclusion, the TRAV31 gene is a pseudogene with a wide range of expression patterns across various cell types. While its functional significance is still unclear, studies have suggested that TRAV31 may play a role in the regulation of gene expression, cell cycle, and apoptosis. Further research is needed to fully understand the clinical significance of TRAV31 and its potential roles in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.