Details for: TRAJ59

Gene ID: 28696

Symbol: TRAJ59

Ensembl ID: ENSG00000211832

Description: T cell receptor alpha joining 59 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.0658
    Cell Significance Index: 13.4700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0605
    Cell Significance Index: 0.7800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0420
    Cell Significance Index: 0.4700
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0002
    Cell Significance Index: -0.0700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0087
    Cell Significance Index: -0.0800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0147
    Cell Significance Index: -0.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0178
    Cell Significance Index: -0.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0220
    Cell Significance Index: -0.4400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0322
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0415
    Cell Significance Index: -0.3900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0906
    Cell Significance Index: -0.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional T cell receptor alpha joining 59**: TRAJ59 lacks the essential functional domains required for T cell receptor alpha joining, rendering it incapable of participating in T cell receptor-mediated immune responses. 2. **Specific expression in neural populations**: TRAJ59 is significantly expressed in caudal ganglionic eminence-derived GABAergic cortical interneurons, vip GABAergic cortical interneurons, and sncg GABAergic cortical interneurons, suggesting a potential role in neural development and function. 3. **Lack of known immunological functions**: Despite its expression in neural cells, TRAJ59 does not possess any known immunological functions, making it an enigmatic gene that warrants further investigation. **Pathways and Functions:** 1. **Neural development and function**: The expression of TRAJ59 in specific neural populations suggests that it may play a role in neural development, particularly in the formation and maturation of GABAergic cortical interneurons. 2. **Neurotransmitter regulation**: The presence of TRAJ59 in vip GABAergic cortical interneurons, which are involved in regulating neurotransmitter release, may indicate a potential role in modulating GABAergic neurotransmission. 3. **Gene regulation and expression**: The study of TRAJ59 may provide insights into the regulation of gene expression in specific neural populations and the mechanisms underlying neural development and function. **Clinical Significance:** 1. **Neurological disorders**: The expression of TRAJ59 in neural populations may be associated with neurological disorders, such as epilepsy, schizophrenia, or autism spectrum disorder, which are characterized by abnormalities in neural development and function. 2. **Neurodevelopmental disorders**: The study of TRAJ59 may provide valuable information about the underlying mechanisms of neurodevelopmental disorders, such as intellectual disability or cognitive impairment. 3. **Gene therapy and targeted therapies**: The identification of TRAJ59's potential role in neural development and function may lead to the development of gene therapies or targeted therapies aimed at modulating GABAergic neurotransmission or neural development. In conclusion, the TRAJ59 gene is an enigmatic gene that warrants further investigation into its potential role in neural development and function. The study of this gene may provide valuable insights into the underlying mechanisms of neurological disorders and the development of targeted therapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.