Details for: TRAJ46

Gene ID: 28709

Symbol: TRAJ46

Ensembl ID: ENSG00000211843

Description: T cell receptor alpha joining 46

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0490
    Cell Significance Index: 0.5500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0069
    Cell Significance Index: -0.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0135
    Cell Significance Index: -0.1300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0142
    Cell Significance Index: -0.1800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0143
    Cell Significance Index: -0.1900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0148
    Cell Significance Index: -0.2000
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0154
    Cell Significance Index: -0.1300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0154
    Cell Significance Index: -0.1500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0161
    Cell Significance Index: -0.1500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0163
    Cell Significance Index: -0.2100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0171
    Cell Significance Index: -0.1500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0181
    Cell Significance Index: -0.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** TRAJ46 is expressed in multiple cell types, including mature NK T cells, alpha-beta T cells, B cells, stromal cells, retinal rod cells, and CD4-positive and CD8-positive T cells. 2. **Gene Structure:** The TRAJ46 gene is a single copy gene, and its structure remains largely uncharacterized. 3. **Function:** The precise function of TRAJ46 is still unknown, but it is thought to play a role in the regulation of immune cell development, function, and interactions. **Pathways and Functions:** 1. **Immune Cell Development:** TRAJ46 may play a role in the development and maturation of immune cells, including T cells and B cells. 2. **Immune Cell Signaling:** TRAJ46 could be involved in the regulation of immune cell signaling pathways, including those mediated by T cell receptors and cytokine receptors. 3. **Stromal Cell Regulation:** TRAJ46 may also regulate the function of stromal cells, which are essential for the maintenance of immune homeostasis. 4. **Neuroimmunity:** The expression of TRAJ46 in retinal rod cells suggests a potential role in neuroimmunity, where the immune system interacts with the nervous system. **Clinical Significance:** 1. **Immunodeficiency Diseases:** Dysregulation of TRAJ46 expression may contribute to immunodeficiency diseases, such as autoimmune disorders and cancer. 2. **Autoimmune Diseases:** TRAJ46 may play a role in the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 3. **Cancer:** Aberrant expression of TRAJ46 may contribute to cancer development and progression. 4. **Neurological Disorders:** The involvement of TRAJ46 in neuroimmunity suggests a potential role in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, the TRAJ46 gene is a complex and multifaceted component of the immune system that plays a crucial role in the regulation of immune cell development, function, and interactions. Further research is necessary to fully elucidate the function and clinical significance of TRAJ46, but its involvement in immune homeostasis and disease suggests that it is a critical gene worth studying.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.