Details for: MIR190A

Gene ID: 406965

Symbol: MIR190A

Ensembl ID: ENSG00000211137

Description: microRNA 190a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0811
    Cell Significance Index: 1.0300
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.0305
    Cell Significance Index: 0.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0082
    Cell Significance Index: 0.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0019
    Cell Significance Index: 0.0400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0030
    Cell Significance Index: -0.0200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0037
    Cell Significance Index: -0.0300
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0191
    Cell Significance Index: -0.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **MicroRNA structure**: MIR190a is a 22-nucleotide long RNA molecule that belongs to the microRNA family. It is composed of a 5' untranslated region (5' UTR), a coding region, and a 3' untranslated region (3' UTR). 2. **Target recognition**: MIR190a recognizes and binds to specific messenger RNA (mRNA) molecules, leading to their degradation or inhibition of translation. 3. **Regulatory role**: MIR190a regulates gene expression by modulating the translation of target mRNAs, thereby influencing cellular development, differentiation, and function. **Pathways and Functions:** 1. **Mirna-mediated post-transcriptional gene silencing**: MIR190a is involved in the regulation of gene expression through the degradation of target mRNAs or inhibition of their translation. 2. **Risc complex**: MIR190a interacts with the RNA-induced silencing complex (RISC), a protein-mRNA complex that plays a crucial role in the recognition and degradation of target mRNAs. 3. **Cellular development and differentiation**: MIR190a regulates the expression of genes involved in cell development, differentiation, and proliferation, including genes involved in neuronal development, immune cell development, and cardiac muscle development. 4. **Immune response**: MIR190a is involved in the regulation of immune cell development and function, including the development of innate lymphoid cells and the regulation of immune responses. **Clinical Significance:** 1. **Cardiovascular disease**: MIR190a has been implicated in the regulation of cardiac muscle development and function, and its dysregulation has been associated with cardiovascular disease. 2. **Neurological disorders**: MIR190a has been shown to play a role in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Immune system disorders**: MIR190a is involved in the regulation of immune cell development and function, and its dysregulation has been associated with immune system disorders such as autoimmune diseases and immunodeficiency disorders. 4. **Cancer**: MIR190a has been shown to play a role in the regulation of cell proliferation and apoptosis, and its dysregulation has been implicated in cancer development and progression. In conclusion, MIR190a is a critical regulator of cellular development, differentiation, and function in the immune system and beyond. Its dysregulation has been implicated in various diseases, including cardiovascular disease, neurological disorders, immune system disorders, and cancer. Further research is needed to fully understand the mechanisms by which MIR190a regulates gene expression and to explore its potential as a therapeutic target for the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.