Details for: MIR520E

Gene ID: 574461

Symbol: MIR520E

Ensembl ID: ENSG00000207599

Description: microRNA 520e

Associated with

  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Positive regulation of complement activation, alternative pathway
    (GO:0045958)
  • Positive regulation of protein localization to cell surface
    (GO:2000010)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 5.43
    Marker Score: 2405
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 5.05
    Marker Score: 2408
  • Cell Name: pericyte (CL0000669)
    Fold Change: 4.03
    Marker Score: 2356
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 3.99
    Marker Score: 2397
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 2.47
    Marker Score: 1969
  • Cell Name: brush cell (CL0002204)
    Fold Change: 1.83
    Marker Score: 1668
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.48
    Marker Score: 2397
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.44
    Marker Score: 9556
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.18
    Marker Score: 2243
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2313
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.08
    Marker Score: 3222
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.04
    Marker Score: 6321
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30330
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.88
    Marker Score: 2243
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4612
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.37
    Marker Score: 2228
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.12
    Marker Score: 1862

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **MicroRNA function:** MIR520E is a microRNA that regulates gene expression through the inhibition of translation or the promotion of degradation of target mRNAs. 2. **Cell-type specificity:** MIR520E is expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, pericytes, lymphoid lineage-restricted progenitor cells, and intestinal enteroendocrine cells. 3. **Regulation of complement activation:** MIR520E is involved in the positive regulation of complement activation, an essential component of the immune response. 4. **Base-pairing translational repressor activity:** MIR520E exhibits base-pairing translational repressor activity, which allows it to regulate the translation of specific mRNAs. **Pathways and Functions:** 1. **Mirna-mediated gene silencing by inhibition of translation:** MIR520E regulates gene expression by inhibiting the translation of target mRNAs, thereby reducing protein production. 2. **Mirna-mediated post-transcriptional gene silencing:** MIR520E promotes the degradation of target mRNAs, leading to the silencing of gene expression. 3. **Mrna base-pairing translational repressor activity:** MIR520E regulates the translation of specific mRNAs through base-pairing interactions. 4. **Positive regulation of complement activation:** MIR520E is involved in the positive regulation of complement activation, an essential component of the immune response. 5. **Positive regulation of protein localization to cell surface:** MIR520E regulates the localization of proteins to the cell surface, which is crucial for various cellular processes. **Clinical Significance:** 1. **Immune system disorders:** Abnormal expression of MIR520E has been linked to immune system disorders, including autoimmune diseases and cancer. 2. **Cardiovascular diseases:** MIR520E has been implicated in the regulation of cardiovascular function and may play a role in the development of cardiovascular diseases. 3. **Neurological disorders:** MIR520E has been observed to be expressed in neuronal cells and may be involved in the regulation of neuronal function, which is critical for neurological disorders such as Alzheimer's disease and Parkinson's disease. 4. **Cancer:** MIR520E has been shown to be downregulated in various types of cancer, suggesting its potential role as a tumor suppressor. In conclusion, MIR520E is a small non-coding RNA that plays a crucial role in regulating various cellular processes, including gene expression, cell signaling, and immune response. Its dysregulation has been implicated in various diseases, including immune system disorders, cardiovascular diseases, and cancer. Further research is needed to fully understand the role of MIR520E in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.