Details for: MIR506

Gene ID: 574511

Symbol: MIR506

Ensembl ID: ENSG00000207731

Description: microRNA 506

Associated with

  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of cellular biosynthetic process
    (GO:0031327)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Positive regulation of cell adhesion molecule production
    (GO:0060355)
  • Positive regulation of gene expression
    (GO:0010628)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 5.05
    Marker Score: 2410
  • Cell Name: pericyte (CL0000669)
    Fold Change: 4.06
    Marker Score: 2370
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 3.98
    Marker Score: 2392
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 2.47
    Marker Score: 1969
  • Cell Name: brush cell (CL0002204)
    Fold Change: 1.83
    Marker Score: 1668
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.48
    Marker Score: 2397
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.44
    Marker Score: 9556
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.22
    Marker Score: 2313
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2326
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.08
    Marker Score: 3222
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.04
    Marker Score: 6321
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30330
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.91
    Marker Score: 2313
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4612
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.38
    Marker Score: 2303
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.13
    Marker Score: 2086

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Other Information

**Key Characteristics** MIR506 is a 22-nucleotide long non-coding RNA molecule that belongs to the microRNA family. It is highly conserved across species, suggesting its importance in evolutionarily conserved biological processes. MIR506 is primarily expressed in specific cell types, including those involved in immune responses, cardiovascular development, and cellular differentiation. Its expression is tightly regulated and is often associated with cell-specific transcriptional programs. **Pathways and Functions** MIR506 is involved in several cellular pathways, including: 1. **MicroRNA-mediated post-transcriptional gene silencing**: MIR506 regulates gene expression by binding to target mRNAs and preventing their translation into proteins. 2. **mRNA 3'-UTR binding**: MIR506 binds to the 3'-untranslated region (3'-UTR) of target mRNAs, regulating their stability and translation. 3. **mRNA base-pairing translational repressor activity**: MIR506 binds to specific sequences in the 3'-UTR of target mRNAs, preventing their translation. 4. **Negative regulation of cellular biosynthetic process**: MIR506 regulates gene expression involved in cellular metabolism, proliferation, and differentiation. 5. **Negative regulation of gene expression**: MIR506 represses the expression of target genes involved in various cellular processes. 6. **Negative regulation of interleukin-8 production**: MIR506 regulates the expression of IL-8, a pro-inflammatory cytokine, in immune cells. 7. **Positive regulation of cell adhesion molecule production**: MIR506 regulates the expression of cell adhesion molecules, such as E-cadherin, in epithelial cells. 8. **Positive regulation of gene expression**: MIR506 activates the expression of target genes involved in cellular differentiation, proliferation, and survival. **Clinical Significance** Dysregulation of MIR506 has been implicated in various diseases, including: 1. **Cardiovascular diseases**: MIR506 has been shown to regulate the expression of genes involved in cardiovascular development and function. 2. **Immune disorders**: MIR506 regulates the expression of genes involved in immune responses, including the production of pro-inflammatory cytokines. 3. **Cancer**: MIR506 has been implicated in the regulation of gene expression involved in cancer development and progression. 4. **Neurological disorders**: MIR506 has been shown to regulate the expression of genes involved in neurological development and function. In conclusion, MIR506 is a small non-coding RNA molecule that plays a crucial role in regulating gene expression at the post-transcriptional level. Its dysregulation has been implicated in various diseases, highlighting the importance of MIR506 in maintaining cellular homeostasis and overall health.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.