Details for: IKBKE
Associated with
Other Information
Genular Protein ID: 410546606
Symbol: IKKE_HUMAN
Name: Inhibitor of nuclear factor kappa-B kinase subunit epsilon
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10421793
Title: IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.
PubMed ID: 10421793
PubMed ID: 10882136
Title: IKK epsilon is part of a novel PMA-inducible IkappaB kinase complex.
PubMed ID: 10882136
PubMed ID: 8590280
Title: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 8590280
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14560022
Title: Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.
PubMed ID: 14560022
PubMed ID: 14739303
Title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.
PubMed ID: 14739303
PubMed ID: 16281057
Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
PubMed ID: 16281057
PubMed ID: 16177806
Title: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
PubMed ID: 16177806
DOI: 10.1038/nature04193
PubMed ID: 17568778
Title: SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.
PubMed ID: 17568778
PubMed ID: 17600090
Title: Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.
PubMed ID: 17600090
PubMed ID: 18583960
Title: The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
PubMed ID: 18583960
PubMed ID: 18636090
Title: Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.
PubMed ID: 18636090
PubMed ID: 18636086
Title: The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
PubMed ID: 18636086
PubMed ID: 19153231
Title: Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.
PubMed ID: 19153231
DOI: 10.1128/jvi.01875-08
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20188669
Title: SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death.
PubMed ID: 20188669
PubMed ID: 20657822
Title: Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion.
PubMed ID: 20657822
PubMed ID: 21138416
Title: Novel cross-talk within the IKK family controls innate immunity.
PubMed ID: 21138416
DOI: 10.1042/bj20101701
PubMed ID: 21464307
Title: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
PubMed ID: 21464307
PubMed ID: 22532683
Title: Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKepsilon.
PubMed ID: 22532683
DOI: 10.1128/jvi.00187-12
PubMed ID: 23453969
Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
PubMed ID: 23453969
PubMed ID: 23478265
Title: Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation.
PubMed ID: 23478265
DOI: 10.1128/mcb.01603-12
PubMed ID: 24882218
Title: Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated antiviral response.
PubMed ID: 24882218
PubMed ID: 24706939
Title: Viral suppression of innate immunity via spatial isolation of TBK1/IKKepsilon from mitochondrial antiviral platform.
PubMed ID: 24706939
DOI: 10.1093/jmcb/mju015
PubMed ID: 26101251
Title: FKBP51 employs both scaffold and isomerase functions to promote NF-kappaB activation in melanoma.
PubMed ID: 26101251
DOI: 10.1093/nar/gkv615
PubMed ID: 27980081
Title: DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.
PubMed ID: 27980081
DOI: 10.1042/bcj20160956
PubMed ID: 28011935
Title: TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.
PubMed ID: 28011935
PubMed ID: 28768861
Title: Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ.
PubMed ID: 28768861
DOI: 10.1128/jvi.00853-17
PubMed ID: 29251827
Title: Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.
PubMed ID: 29251827
PubMed ID: 31434731
Title: Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses.
PubMed ID: 31434731
DOI: 10.1128/jvi.01159-19
PubMed ID: 33391252
Title: Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-beta Activity by Inhibiting the Activation of IRF3.
PubMed ID: 33391252
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 716
- Mass: 80462
- Checksum: 3E5FBE5840734D81
- Sequence:
MQSTANYLWH TDDLLGQGAT ASVYKARNKK SGELVAVKVF NTTSYLRPRE VQVREFEVLR KLNHQNIVKL FAVEETGGSR QKVLVMEYCS SGSLLSVLES PENAFGLPED EFLVVLRCVV AGMNHLRENG IVHRDIKPGN IMRLVGEEGQ SIYKLTDFGA ARELDDDEKF VSVYGTEEYL HPDMYERAVL RKPQQKAFGV TVDLWSIGVT LYHAATGSLP FIPFGGPRRN KEIMYRITTE KPAGAIAGAQ RRENGPLEWS YTLPITCQLS LGLQSQLVPI LANILEVEQA KCWGFDQFFA ETSDILQRVV VHVFSLSQAV LHHIYIHAHN TIAIFQEAVH KQTSVAPRHQ EYLFEGHLCV LEPSVSAQHI AHTTASSPLT LFSTAIPKGL AFRDPALDVP KFVPKVDLQA DYNTAKGVLG AGYQALRLAR ALLDGQELMF RGLHWVMEVL QATCRRTLEV ARTSLLYLSS SLGTERFSSV AGTPEIQELK AAAELRSRLR TLAEVLSRCS QNITETQESL SSLNRELVKS RDQVHEDRSI QQIQCCLDKM NFIYKQFKKS RMRPGLGYNE EQIHKLDKVN FSHLAKRLLQ VFQEECVQKY QASLVTHGKR MRVVHETRNH LRLVGCSVAA CNTEAQGVQE SLSKLLEELS HQLLQDRAKG AQASPPPIAP YPSPTRKDLL LHMQELCEGM KLLASDLLDN NRIIERLNRV PAPPDV
Genular Protein ID: 1914938994
Symbol: A0A075B7B4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 657
- Mass: 73750
- Checksum: 1CAA01732C543B32
- Sequence:
MQSTANYLWH TDDLLGQGAT ASVYKARNKK SGELVAVKVF NTTSYLRPRE VQVREFEVLR KLNHQNIVKL FAVEETGGSR QKVLVMEYCS SGSLLSVLES PENAFGLPED EFLVVLRCVV AGMNHLRENG IVHRDIKPGN IMRLVGEEGQ SIYKLTDFGA ARELDDDEKF VSVYGTEEYL HPDMYERAVL RKPQQKAFGV TVDLWSIGVT LYHAATGSLP FIPFGGPRRN KEIMYRITTE KPAGAIAGAQ RRENGPLEWS YTLPITCQLS LGLQSQLVPI LANILEVEQA KCWGFDQFFA ETSDILQRVV VHVFSLSQAV LHHIYIHAHN TIAIFQEAVH KQTSVAPRHQ EYLFEGHLCV LEPSVSAQHI AHTTASSPLT LFSTAIPKGL AFRDPALDVP KFVPKVDLQA DYNTAKGVLG AGYQALRLAR ALLDGQELMF RGLHWVMEVL QATCRRTLEV ARTSLLYLSS SLGTERFSSV AGTPEIQELK AAAELRSRLR TLAEVLSRCS QNITETQESL SSLNRELVKS RDQVHEDRSI QQIQCCLDKM NFIYKQFKKS RMRPGLGYNE EQIHKLDKVN FSHLAKRLLQ VFQEECVQKY QASLVTHGKR MRVVHETRNH LRLVGCSVAA CNTEAQGVQE SLSKHARALR GDEAAGI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.