Details for: NAT2

Gene ID: 10

Symbol: NAT2

Ensembl ID: ENSG00000156006

Description: N-acetyltransferase 2

Associated with

Cells (max top 100)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.17
    Marker Score: 2188
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.67
    Marker Score: 1154.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.64
    Marker Score: 3107
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.05
    Marker Score: 1000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 665.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1763
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1397
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 474
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12776
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2877.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.68
    Marker Score: 3287
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 402
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 427.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 389
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.62
    Marker Score: 3975
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.62
    Marker Score: 2664
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 475
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.48
    Marker Score: 2604
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 126
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 196.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 742
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 206
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 171
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.36
    Marker Score: 548
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.33
    Marker Score: 1034
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.3
    Marker Score: 86
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 293
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.29
    Marker Score: 186
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.28
    Marker Score: 654
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.27
    Marker Score: 100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.26
    Marker Score: 277
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.24
    Marker Score: 171
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.24
    Marker Score: 58
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.23
    Marker Score: 157
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.23
    Marker Score: 253.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.2
    Marker Score: 188
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.19
    Marker Score: 267
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 377
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.16
    Marker Score: 1094
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.15
    Marker Score: 102
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.14
    Marker Score: 217
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.12
    Marker Score: 198
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 84.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 115
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 130
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 132
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1
    Marker Score: 78
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 223
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 20.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 120
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 153
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.06
    Marker Score: 106
**Key characteristics:** * The NAT2 gene is located on chromosome 15q21.1. * It is a large gene, encoding a protein of 1,594 amino acids. * The protein is expressed in a variety of cell types, including blood vessel endothelial cells, conventional dendritic cells, cardiac endothelial cells, granulocyte monocyte progenitor cells, B cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, tuft cells of the colon, and human absorptive cells. **Pathways and functions:** * The NAT2 gene is involved in several metabolic pathways, including acetylation, arylamine n-acetyltransferase activity, biological oxidations, cytosol, drug adme, metabolism, paracetamol adme, phase II - conjugation of compounds, and xenobiotic metabolic process. * The protein is involved in the metabolism of a variety of drugs, including paracetamol and methadone. * It is also involved in the detoxification of carcinogens. **Clinical significance:** * Mutations in the NAT2 gene have been linked to several human diseases, including liver disease, cancer, and drug addiction. * The NAT2 gene is a promising target for the development of new drugs to treat these diseases. **Additional information:** * The NAT2 gene is also known as NR1. * It is a highly expressed gene, with high levels of expression in the liver, kidney, and lungs. * Mutations in the NAT2 gene have been shown to be associated with an increased risk of developing liver disease, cancer, and drug addiction.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.