Details for: NAT2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.4051
Cell Significance Index: 40.4900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.1559
Cell Significance Index: 17.3200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0623
Cell Significance Index: 63.7800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.0266
Cell Significance Index: -2.7500 - Cell Name: precursor cell (CL0011115)
Fold Change: 0.9469
Cell Significance Index: 7.1800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8816
Cell Significance Index: 19.1000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7343
Cell Significance Index: 79.8700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.7301
Cell Significance Index: 17.6900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7002
Cell Significance Index: 632.2100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6471
Cell Significance Index: 29.3300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5395
Cell Significance Index: 11.4900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.5063
Cell Significance Index: 7.6300 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.4741
Cell Significance Index: 6.9100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4459
Cell Significance Index: 9.2500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4444
Cell Significance Index: 72.2900 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.4361
Cell Significance Index: 6.1200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4126
Cell Significance Index: 28.5400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4044
Cell Significance Index: 40.0000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3490
Cell Significance Index: 66.4200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2979
Cell Significance Index: 9.5400 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.2954
Cell Significance Index: 5.0500 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.1928
Cell Significance Index: 2.0900 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.1658
Cell Significance Index: 2.6300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.1106
Cell Significance Index: 1.8600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0810
Cell Significance Index: 1.1600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0808
Cell Significance Index: 2.0200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0808
Cell Significance Index: 2.1700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0610
Cell Significance Index: 0.9000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0528
Cell Significance Index: 1.4100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0519
Cell Significance Index: 2.4200 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.0416
Cell Significance Index: 0.5800 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.0355
Cell Significance Index: 0.2200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0333
Cell Significance Index: 0.3500 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.0229
Cell Significance Index: 0.3900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0222
Cell Significance Index: 0.7800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0155
Cell Significance Index: 3.0800 - Cell Name: colonocyte (CL1000347)
Fold Change: 0.0113
Cell Significance Index: 0.0700 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.0111
Cell Significance Index: 0.1100 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.0057
Cell Significance Index: 0.0400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0039
Cell Significance Index: 0.2000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0018
Cell Significance Index: 0.2300 - Cell Name: stem cell (CL0000034)
Fold Change: 0.0014
Cell Significance Index: 0.0100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0012
Cell Significance Index: 0.1700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0001
Cell Significance Index: -0.2000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0006
Cell Significance Index: -1.1200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0008
Cell Significance Index: -1.1200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0009
Cell Significance Index: -0.0100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0009
Cell Significance Index: -0.2600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0010
Cell Significance Index: -0.5400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0014
Cell Significance Index: -0.1600 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0015
Cell Significance Index: -0.0100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0017
Cell Significance Index: -1.2500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0022
Cell Significance Index: -1.2500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0026
Cell Significance Index: -0.9200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0027
Cell Significance Index: -1.9800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0029
Cell Significance Index: -0.1300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0034
Cell Significance Index: -2.1300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0036
Cell Significance Index: -0.7300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0041
Cell Significance Index: -1.8600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0044
Cell Significance Index: -0.5100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0044
Cell Significance Index: -0.1800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0053
Cell Significance Index: -0.2700 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0059
Cell Significance Index: -0.0600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0071
Cell Significance Index: -1.2200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0077
Cell Significance Index: -0.4800 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.0085
Cell Significance Index: -0.1000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0093
Cell Significance Index: -1.6700 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0125
Cell Significance Index: -0.2000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0155
Cell Significance Index: -1.1900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0157
Cell Significance Index: -2.2800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0173
Cell Significance Index: -1.1600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0178
Cell Significance Index: -2.1900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0195
Cell Significance Index: -0.5400 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0197
Cell Significance Index: -0.2600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0201
Cell Significance Index: -2.0500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0202
Cell Significance Index: -0.5500 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0205
Cell Significance Index: -0.4000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0205
Cell Significance Index: -0.4300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0205
Cell Significance Index: -0.5300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0219
Cell Significance Index: -1.2300 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: -0.0256
Cell Significance Index: -0.1500 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0265
Cell Significance Index: -0.2800 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0267
Cell Significance Index: -0.6800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0285
Cell Significance Index: -1.2600 - Cell Name: goblet cell (CL0000160)
Fold Change: -0.0287
Cell Significance Index: -0.2600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0299
Cell Significance Index: -0.9800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0300
Cell Significance Index: -1.0500 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0300
Cell Significance Index: -0.4000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0307
Cell Significance Index: -1.8900 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0311
Cell Significance Index: -0.3400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0321
Cell Significance Index: -1.1800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0322
Cell Significance Index: -1.2200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0323
Cell Significance Index: -0.8700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0324
Cell Significance Index: -2.5700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0338
Cell Significance Index: -1.0800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0350
Cell Significance Index: -1.0300 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0353
Cell Significance Index: -0.4000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0364
Cell Significance Index: -0.6000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0370
Cell Significance Index: -1.0600 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: -0.0373
Cell Significance Index: -0.2200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3740407562
Symbol: ARY2_HUMAN
Name: Arylamide acetylase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2734109
Title: Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation.
PubMed ID: 2734109
PubMed ID: 2340091
Title: Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.
PubMed ID: 2340091
PubMed ID: 1968463
Title: Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver.
PubMed ID: 1968463
PubMed ID: 1381364
Title: Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver.
PubMed ID: 1381364
PubMed ID: 7915226
Title: Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.
PubMed ID: 7915226
PubMed ID: 16416399
Title: Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.
PubMed ID: 16416399
DOI: 10.1086/500614
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1676262
Title: Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases.
PubMed ID: 1676262
PubMed ID: 2924904
Title: Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver.
PubMed ID: 2924904
PubMed ID: 17656365
Title: Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases.
PubMed ID: 17656365
PubMed ID: 2068113
Title: Diverse point mutations in the human gene for polymorphic N-acetyltransferase.
PubMed ID: 2068113
PubMed ID: 8466518
Title: The structure and characteristics of a fourth allele of polymorphic N-acetyltransferase gene found in the Japanese population.
PubMed ID: 8466518
PubMed ID: 7920692
Title: Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene.
PubMed ID: 7920692
PubMed ID: 10970160
Title: Novel allele containing a 190C>T nonsynonymous substitution in the N-acetyltransferase (NAT2) gene.
PubMed ID: 10970160
DOI: 10.1002/1098-1004(200006)15:6<581::aid-humu17>3.0.co;2-v
PubMed ID: 11337936
Title: Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.
PubMed ID: 11337936
PubMed ID: 12222688
Title: Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.
PubMed ID: 12222688
DOI: 10.1515/bc.2002.105
PubMed ID: 17264801
Title: Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2.
PubMed ID: 17264801
PubMed ID: 18304320
Title: Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history.
PubMed ID: 18304320
Sequence Information:
- Length: 290
- Mass: 33571
- Checksum: FAEE3BC2107F000E
- Sequence:
MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL GLEAIFDHIV RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK YSTGMVHLLL QVTIDGRNYI VDAGSGSSSQ MWQPLELISG KDQPQVPCIF CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT YRKFNYKDNT DLVEFKTLTE EEVEEVLRNI FKISLGRNLV PKPGDGSLTI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.