NAT2 - ENSG00000156006

Details for: NAT2

Gene ID: 10

Symbol: NAT2

Ensembl ID: ENSG00000156006

Description: N-acetyltransferase 2

Associated with

Acetylation (R-HSA-156582)
Biological oxidations (R-HSA-211859)
Drug adme (R-HSA-9748784)
Metabolism (R-HSA-1430728)
Paracetamol adme (R-HSA-9753281)
Phase ii - conjugation of compounds (R-HSA-156580)
Arylamine n-acetyltransferase activity (GO:0004060)
Cytosol (GO:0005829)
Protein binding (GO:0005515)
Xenobiotic metabolic process (GO:0006805)

Cells (max top 100)

Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.17
Marker Score: 2188
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.67
Marker Score: 1154.5
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.64
Marker Score: 3107
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 874
Cell Name: B cell (CL0000236)
Fold Change: 1.05
Marker Score: 1000
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71829
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48055
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 512
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 465
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 376
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5341
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 328
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5289
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.87
Marker Score: 665.5
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.87
Marker Score: 1763
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.86
Marker Score: 1397
Cell Name: mast cell (CL0000097)
Fold Change: 0.82
Marker Score: 474
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.82
Marker Score: 12776
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 701
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2877.5
Cell Name: enterocyte (CL0000584)
Fold Change: 0.68
Marker Score: 3287
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.67
Marker Score: 402
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.65
Marker Score: 427.5
Cell Name: neutrophil (CL0000775)
Fold Change: 0.64
Marker Score: 389
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.62
Marker Score: 3975
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.62
Marker Score: 2664
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 475
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.5
Marker Score: 478
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.48
Marker Score: 2604
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.48
Marker Score: 126
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.47
Marker Score: 196.5
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 279
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.46
Marker Score: 742
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 374
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.36
Marker Score: 206
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.36
Marker Score: 171
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.36
Marker Score: 548
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.33
Marker Score: 1034
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.3
Marker Score: 86
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.29
Marker Score: 293
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.29
Marker Score: 186
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.28
Marker Score: 124
Cell Name: stem cell (CL0000034)
Fold Change: 0.28
Marker Score: 654
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.27
Marker Score: 100
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.26
Marker Score: 277
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.24
Marker Score: 171
Cell Name: precursor cell (CL0011115)
Fold Change: 0.24
Marker Score: 58
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.23
Marker Score: 157
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: plasma cell (CL0000786)
Fold Change: 0.23
Marker Score: 253.5
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.22
Marker Score: 117
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.2
Marker Score: 188
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.19
Marker Score: 267
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.19
Marker Score: 70
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.18
Marker Score: 377
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.17
Marker Score: 70
Cell Name: goblet cell (CL0000160)
Fold Change: 0.16
Marker Score: 1094
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.15
Marker Score: 102
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.14
Marker Score: 52
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.14
Marker Score: 36
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.14
Marker Score: 217
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.14
Marker Score: 39
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.13
Marker Score: 41
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.13
Marker Score: 59
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.12
Marker Score: 27
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.12
Marker Score: 198
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.11
Marker Score: 84.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.11
Marker Score: 115
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.11
Marker Score: 32
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.1
Marker Score: 130
Cell Name: monocyte (CL0000576)
Fold Change: 0.1
Marker Score: 132
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.1
Marker Score: 78
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.09
Marker Score: 223
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.09
Marker Score: 20.5
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.09
Marker Score: 120
Cell Name: T cell (CL0000084)
Fold Change: 0.09
Marker Score: 153
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.08
Marker Score: 23
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.08
Marker Score: 18
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.08
Marker Score: 44
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.08
Marker Score: 41
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.07
Marker Score: 23
Cell Name: paneth cell (CL0000510)
Fold Change: 0.07
Marker Score: 51
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.07
Marker Score: 49
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.07
Marker Score: 62
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.07
Marker Score: 20
Cell Name: kidney cell (CL1000497)
Fold Change: 0.07
Marker Score: 45
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.07
Marker Score: 21
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.06
Marker Score: 43
Cell Name: pericyte (CL0000669)
Fold Change: 0.06
Marker Score: 37
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.06
Marker Score: 45
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.06
Marker Score: 18
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.06
Marker Score: 106

**Key characteristics:** * The NAT2 gene is located on chromosome 15q21.1. * It is a large gene, encoding a protein of 1,594 amino acids. * The protein is expressed in a variety of cell types, including blood vessel endothelial cells, conventional dendritic cells, cardiac endothelial cells, granulocyte monocyte progenitor cells, B cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, tuft cells of the colon, and human absorptive cells. **Pathways and functions:** * The NAT2 gene is involved in several metabolic pathways, including acetylation, arylamine n-acetyltransferase activity, biological oxidations, cytosol, drug adme, metabolism, paracetamol adme, phase II - conjugation of compounds, and xenobiotic metabolic process. * The protein is involved in the metabolism of a variety of drugs, including paracetamol and methadone. * It is also involved in the detoxification of carcinogens. **Clinical significance:** * Mutations in the NAT2 gene have been linked to several human diseases, including liver disease, cancer, and drug addiction. * The NAT2 gene is a promising target for the development of new drugs to treat these diseases. **Additional information:** * The NAT2 gene is also known as NR1. * It is a highly expressed gene, with high levels of expression in the liver, kidney, and lungs. * Mutations in the NAT2 gene have been shown to be associated with an increased risk of developing liver disease, cancer, and drug addiction.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.