Details for: NAT2

Gene ID: 10

Symbol: NAT2

Ensembl ID: ENSG00000156006

Description: N-acetyltransferase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.17
    Marker Score: 2188
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.67
    Marker Score: 1154.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.64
    Marker Score: 3107
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.05
    Marker Score: 1000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 665.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1763
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1397
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 474
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12776
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2877.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.68
    Marker Score: 3287
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 402
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 427.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 389
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.62
    Marker Score: 3975
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.62
    Marker Score: 2664
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 475
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.48
    Marker Score: 2604
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 126
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 196.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 742
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 206
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 171
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.36
    Marker Score: 548
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.33
    Marker Score: 1034
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.3
    Marker Score: 86
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 293
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.29
    Marker Score: 186
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.28
    Marker Score: 654
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.27
    Marker Score: 100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.26
    Marker Score: 277
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.24
    Marker Score: 171
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.24
    Marker Score: 58
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.23
    Marker Score: 157
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.23
    Marker Score: 253.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.2
    Marker Score: 188
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.19
    Marker Score: 267
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 377
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.16
    Marker Score: 1094
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.15
    Marker Score: 102
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.14
    Marker Score: 217
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.12
    Marker Score: 198
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 84.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 115
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 130
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 132
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1
    Marker Score: 78
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 223
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 20.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 120
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 153
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.06
    Marker Score: 106

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Other Information

**Key characteristics:** * The NAT2 gene is located on chromosome 15q21.1. * It is a large gene, encoding a protein of 1,594 amino acids. * The protein is expressed in a variety of cell types, including blood vessel endothelial cells, conventional dendritic cells, cardiac endothelial cells, granulocyte monocyte progenitor cells, B cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, tuft cells of the colon, and human absorptive cells. **Pathways and functions:** * The NAT2 gene is involved in several metabolic pathways, including acetylation, arylamine n-acetyltransferase activity, biological oxidations, cytosol, drug adme, metabolism, paracetamol adme, phase II - conjugation of compounds, and xenobiotic metabolic process. * The protein is involved in the metabolism of a variety of drugs, including paracetamol and methadone. * It is also involved in the detoxification of carcinogens. **Clinical significance:** * Mutations in the NAT2 gene have been linked to several human diseases, including liver disease, cancer, and drug addiction. * The NAT2 gene is a promising target for the development of new drugs to treat these diseases. **Additional information:** * The NAT2 gene is also known as NR1. * It is a highly expressed gene, with high levels of expression in the liver, kidney, and lungs. * Mutations in the NAT2 gene have been shown to be associated with an increased risk of developing liver disease, cancer, and drug addiction.

Genular Protein ID: 3740407562

Symbol: ARY2_HUMAN

Name: Arylamine N-acetyltransferase 2

UniProtKB Accession Codes:

P11245 O43637 O60654 O60655 Q13146 Q16697 Q2MLE4 Q2MLF5 Q2MLG8 Q2MLJ6 Q2MLK4 Q2MLK6 Q2MLN7 Q6LET4 Q86XS0 Q86XS1 Q96KY8 Q96T64 Q96T65 Q9H220

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EC 2 EMBL 100 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2734109

Title: Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation.

PubMed ID: 2734109

DOI: 10.1093/nar/17.10.3978

PubMed ID: 2340091

Title: Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.

PubMed ID: 2340091

DOI: 10.1089/dna.1990.9.193

PubMed ID: 1968463

Title: Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver.

PubMed ID: 1968463

DOI: 10.1016/s0021-9258(19)39609-7

PubMed ID: 1381364

Title: Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver.

PubMed ID: 1381364

DOI: 10.1016/s0021-9258(19)37164-9

PubMed ID: 7915226

Title: Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.

PubMed ID: 7915226

PubMed ID: 16416399

Title: Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.

PubMed ID: 16416399

DOI: 10.1086/500614

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1676262

Title: Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases.

PubMed ID: 1676262

DOI: 10.1016/0006-291x(91)90676-x

PubMed ID: 2924904

Title: Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver.

PubMed ID: 2924904

DOI: 10.1016/0014-5793(89)81193-7

PubMed ID: 17656365

Title: Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases.

PubMed ID: 17656365

DOI: 10.1074/jbc.m704138200

PubMed ID: 2068113

Title: Diverse point mutations in the human gene for polymorphic N-acetyltransferase.

PubMed ID: 2068113

DOI: 10.1073/pnas.88.14.6333

PubMed ID: 8466518

Title: The structure and characteristics of a fourth allele of polymorphic N-acetyltransferase gene found in the Japanese population.

PubMed ID: 8466518

DOI: 10.1006/bbrc.1993.1289

PubMed ID: 7920692

Title: Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene.

PubMed ID: 7920692

DOI: 10.1097/00008571-199406000-00003

Sequence Information:

  • Length: 290
  • Mass: 33571
  • Checksum: FAEE3BC2107F000E
  • Sequence:
    • MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL GLEAIFDHIV 
RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK YSTGMVHLLL QVTIDGRNYI 
VDAGSGSSSQ MWQPLELISG KDQPQVPCIF CLTEERGIWY LDQIRREQYI TNKEFLNSHL 
LPKKKHQKIY LFTLEPRTIE DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT 
YRKFNYKDNT DLVEFKTLTE EEVEEVLRNI FKISLGRNLV PKPGDGSLTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.