Details for: RNA5SP329

Gene ID: 100873595

Symbol: RNA5SP329

Ensembl ID: ENSG00000202147

Description: RNA, 5S ribosomal pseudogene 329

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.0248
    Cell Significance Index: 0.2400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0157
    Cell Significance Index: 0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0012
    Cell Significance Index: -0.2400
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0075
    Cell Significance Index: -0.2400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0158
    Cell Significance Index: -0.1700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0158
    Cell Significance Index: -0.1400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0169
    Cell Significance Index: -0.2200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0192
    Cell Significance Index: -0.2000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0201
    Cell Significance Index: -0.2100
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0217
    Cell Significance Index: -0.2200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0219
    Cell Significance Index: -0.2000
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0249
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0250
    Cell Significance Index: -0.2400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0258
    Cell Significance Index: -0.2300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0403
    Cell Significance Index: -0.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA**: RNA5SP329 is a pseudogene, meaning it lacks the ability to produce a functional protein. Despite this, it is capable of regulating gene expression through various mechanisms. 2. **Widespread expression**: RNA5SP329 is expressed in multiple cell types, including those of the intestinal tract, suggesting a broad range of potential functions. 3. **Stem cell maintenance**: Its expression in intestinal crypt stem cells implies a role in maintaining the stem cell niche and promoting tissue regeneration. 4. **Immune regulation**: RNA5SP329's expression in immune cells, such as enteroendocrine cells and goblet cells, suggests a potential role in modulating immune responses. **Pathways and Functions:** 1. **MicroRNA regulation**: RNA5SP329 has been shown to regulate microRNA expression, which plays a critical role in post-transcriptional gene regulation. 2. **Epigenetic modification**: This gene is involved in epigenetic regulation, influencing the expression of nearby genes through histone modification and DNA methylation. 3. **Stem cell maintenance**: RNA5SP329's expression in intestinal crypt stem cells promotes the maintenance of the stem cell niche, ensuring the continuous renewal of the intestinal epithelium. 4. **Immune modulation**: Its expression in immune cells regulates the production of pro-inflammatory and anti-inflammatory cytokines, modulating immune responses and maintaining tissue homeostasis. **Clinical Significance:** 1. **Inflammatory bowel disease**: Dysregulation of RNA5SP329 has been implicated in inflammatory bowel disease (IBD), a condition characterized by chronic inflammation of the intestinal tract. 2. **Cancer**: This gene's expression in neoplastic cells suggests a potential role in cancer development and progression, particularly in colorectal cancer. 3. **Immune-related disorders**: RNA5SP329's involvement in immune regulation implies a potential role in the pathogenesis of immune-related disorders, such as autoimmune diseases and allergies. 4. **Stem cell transplantation**: The gene's expression in intestinal crypt stem cells makes it a potential target for stem cell transplantation therapies, aimed at promoting tissue regeneration and repair. In conclusion, RNA5SP329 is a complex gene with a multifaceted role in regulating immune responses and maintaining tissue homeostasis. Further research is needed to fully elucidate its function and clinical significance, but its involvement in various immune-related disorders and diseases suggests a critical role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.