Details for: RNU4 30P

Gene ID: 106479571

Symbol: RNU4 30P

Ensembl ID: ENSG00000222177

Description: RNA, U4 small nuclear 30, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0461
    Cell Significance Index: 0.5500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0314
    Cell Significance Index: 0.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0230
    Cell Significance Index: 0.6200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.0206
    Cell Significance Index: 0.1900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0185
    Cell Significance Index: 0.2100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0051
    Cell Significance Index: 0.0500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0193
    Cell Significance Index: -0.4200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0228
    Cell Significance Index: -0.2600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0273
    Cell Significance Index: -0.2600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0468
    Cell Significance Index: -0.5400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0505
    Cell Significance Index: -0.4800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0514
    Cell Significance Index: -0.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0617
    Cell Significance Index: -0.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** RNU4 30P is classified as a pseudogene, which implies that it lacks a functional coding sequence and does not produce a protein. However, pseudogenes can still contribute to gene regulation and cellular processes through various mechanisms, including RNA interference, chromatin modification, and long-range gene regulation. 2. **Ubiquitous expression:** RNU4 30P is significantly expressed in multiple cell types within the intestinal tissue, including intestinal epithelial cells, goblet cells, and enteroendocrine cells. This widespread expression suggests that RNU4 30P may play a role in maintaining intestinal homeostasis and responding to environmental stimuli. 3. **Cellular localization:** RNU4 30P has been detected in various subpopulations of intestinal cells, including absorptive cells, transit-amplifying cells, and intestinal crypt stem cells. This suggests that RNU4 30P may be involved in regulating cellular processes specific to these cell types. **Pathways and Functions:** While the exact mechanisms underlying RNU4 30P's functions are unclear, several pathways and processes may be implicated: 1. **RNA processing and regulation:** As a pseudogene, RNU4 30P may influence RNA processing and regulation, potentially affecting the expression of nearby genes or participating in long-range gene regulation. 2. **Epigenetic regulation:** RNU4 30P may contribute to epigenetic regulation, influencing chromatin structure and modifying gene expression through histone modifications, DNA methylation, or other epigenetic mechanisms. 3. **Cell signaling and communication:** RNU4 30P's expression in enteroendocrine cells and other cell types suggests that it may participate in cell signaling and communication pathways, influencing cellular behavior and response to environmental stimuli. **Clinical Significance:** The discovery of RNU4 30P's widespread expression in intestinal tissues raises several clinical implications: 1. **Intestinal health and disease:** Abnormal expression or dysregulation of RNU4 30P may contribute to intestinal diseases, such as inflammatory bowel disease (IBD), cancer, or other gastrointestinal disorders. 2. **Cancer biomarkers:** RNU4 30P's expression in neoplastic cells suggests that it may serve as a potential biomarker for cancer diagnosis or prognosis. 3. **Gene therapy and gene editing:** Understanding RNU4 30P's functions and mechanisms may inform the development of gene therapy or gene editing strategies for treating intestinal diseases or disorders. In conclusion, RNU4 30P is a pseudogene with far-reaching implications for our understanding of intestinal biology and disease. Further investigation into its functions and mechanisms will be essential for unraveling the mysteries of this enigmatic gene and its role in maintaining intestinal homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.