Details for: SNORD56

Gene ID: 26793

Symbol: SNORD56

Ensembl ID: ENSG00000229686

Description: small nucleolar RNA, C/D box 56

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0163
    Cell Significance Index: 0.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0008
    Cell Significance Index: -0.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0046
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0047
    Cell Significance Index: -0.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0119
    Cell Significance Index: -0.1600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0152
    Cell Significance Index: -0.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0158
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0169
    Cell Significance Index: -0.2200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0173
    Cell Significance Index: -0.1200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0187
    Cell Significance Index: -0.2000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0201
    Cell Significance Index: -0.2300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0201
    Cell Significance Index: -0.2300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0221
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0222
    Cell Significance Index: -0.2600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0228
    Cell Significance Index: -0.2500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0229
    Cell Significance Index: -0.2700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0316
    Cell Significance Index: -0.2600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0323
    Cell Significance Index: -0.2600
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0435
    Cell Significance Index: -0.2100
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.1051
    Cell Significance Index: -0.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD56 is a small nucleolar RNA (snoRNA) that belongs to the C/D box family of snoRNAs. These snoRNAs are involved in the modification of ribose residues in RNA, specifically in the 5' and 2' positions of rRNA, tRNA, and snRNA. SNORD56 is specifically expressed in various cell types, including pericytes, cardiac endothelial cells, cardiac muscle myoblasts, and immature innate lymphoid cells. Its expression is also observed in other cell types, such as type A enteroendocrine cells, fibroblasts of cardiac tissue, smooth muscle myoblasts, neuronal receptor cells, and acinar cells. **Pathways and Functions:** SNORD56 is involved in the RNA processing pathway, specifically in the modification of rRNA, tRNA, and snRNA. The snoRNA C/D box motif is responsible for binding to the target RNA and facilitating the enzymatic activity of the associated protein, such as Nop1p or Nop2p. This binding enables the snoRNA to catalyze the 2'-O-methylation of ribose residues, which is essential for ribosomal function and protein synthesis. Additionally, SNORD56 may play a role in the regulation of RNA stability and splicing, although further studies are required to elucidate its specific functions. **Clinical Significance:** While SNORD56 is not a well-studied gene, its expression in various cell types suggests that it may play a role in cellular differentiation and development. Abnormal expression of SNORD56 has been implicated in several diseases, including cancer and cardiovascular disorders. For example, alterations in SNORD56 expression have been observed in cardiac myocytes, suggesting that it may be involved in the regulation of cardiac function and development. Furthermore, SNORD56 may have a role in the regulation of innate immune responses, given its expression in immature innate lymphoid cells. In conclusion, SNORD56 is a small non-coding RNA molecule that plays a crucial role in RNA processing and cellular differentiation. Further studies are required to elucidate its specific functions and clinical significance, particularly in the context of diseases such as cancer and cardiovascular disorders. As an expert immunologist, I believe that SNORD56 is an important gene that warrants further investigation to understand its role in human health and disease. **Recommendations:** To further investigate the role of SNORD56 in human health and disease, I recommend the following: 1. Investigate the expression patterns of SNORD56 in various cell types and tissues to better understand its role in cellular differentiation and development. 2. Conduct functional studies to elucidate the specific functions of SNORD56 in RNA processing and cellular differentiation. 3. Examine the relationship between SNORD56 expression and disease, including cancer and cardiovascular disorders. 4. Investigate the potential therapeutic applications of SNORD56 in the treatment of diseases related to RNA processing and cellular differentiation. By pursuing these research directions, we can gain a deeper understanding of the role of SNORD56 in human health and disease, and ultimately develop new therapeutic strategies to target this important gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.