Details for: SNORD52

Gene ID: 26797

Symbol: SNORD52

Ensembl ID: ENSG00000201754

Description: small nucleolar RNA, C/D box 52

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0117
    Cell Significance Index: 0.1400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0019
    Cell Significance Index: -0.5600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0079
    Cell Significance Index: -0.1000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0165
    Cell Significance Index: -0.1600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0229
    Cell Significance Index: -0.2500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0296
    Cell Significance Index: -0.4000
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0360
    Cell Significance Index: -0.2500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0452
    Cell Significance Index: -0.5900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0466
    Cell Significance Index: -0.5000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0481
    Cell Significance Index: -0.5500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0485
    Cell Significance Index: -0.5600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0518
    Cell Significance Index: -0.6100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0519
    Cell Significance Index: -0.6100
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.1244
    Cell Significance Index: -0.6000
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.2844
    Cell Significance Index: -0.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** SNORD52 is expressed in a wide range of cell types, including type A enteroendocrine cells, myeloid cells, macrophages, type D enteroendocrine cells, type B pancreatic cells, acinar cells, oligodendrocyte precursor cells, microglial cells, monocytes, and vascular lymphangioblasts. This broad expression pattern suggests a non-specific or pleiotropic function. 2. **C/D Box Motif:** SNORD52 contains a characteristic C/D box motif, a conserved sequence element found in snoRNAs that guides the assembly of ribonucleoproteins (RNPs) involved in RNA modification and processing. 3. **Nucleolus-Associated:** SNORD52 is localized to the nucleolus, a region within the nucleus responsible for ribosome biogenesis and RNA processing. **Pathways and Functions:** 1. **RNA Processing:** SNORD52 is involved in RNA processing, specifically in the modification of ribosomal RNA (rRNA) and other RNAs. This process is crucial for ribosome biogenesis, protein synthesis, and cell growth. 2. **Nucleolar Organization:** SNORD52 contributes to the organization and regulation of the nucleolus, a complex structure that coordinates ribosome biogenesis and RNA processing. 3. **Cellular Regulation:** SNORD52 may play a role in regulating cellular processes, such as cell growth, differentiation, and survival, by modulating RNA processing and nucleolar activity. **Clinical Significance:** 1. **Disease Association:** SNORD52 has been linked to several diseases, including cancer, where altered expression of this gene may contribute to tumorigenesis and tumour progression. 2. **Neurological Disorders:** SNORD52 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), where altered expression of this gene may contribute to disease pathogenesis. 3. **Immunological Implications:** SNORD52 expression in immune cells, such as macrophages and monocytes, suggests a potential role in immune regulation and modulation of inflammatory responses. In conclusion, SNORD52 is a complex snoRNA with far-reaching implications in cellular processes, including RNA processing, nucleolar organization, and cellular regulation. Further research is needed to fully elucidate the mechanisms underlying its functions and to explore its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.