Details for: SNORD36B

Gene ID: 26814

Symbol: SNORD36B

Ensembl ID: ENSG00000200831

Description: small nucleolar RNA, C/D box 36B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0037
    Cell Significance Index: -0.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0040
    Cell Significance Index: -0.2100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0066
    Cell Significance Index: -0.0600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0087
    Cell Significance Index: -0.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0092
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0095
    Cell Significance Index: -0.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0138
    Cell Significance Index: -0.1800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0159
    Cell Significance Index: -0.1700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0159
    Cell Significance Index: -0.1100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0162
    Cell Significance Index: -0.1900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0166
    Cell Significance Index: -0.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0166
    Cell Significance Index: -0.1900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0181
    Cell Significance Index: -0.2100
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0394
    Cell Significance Index: -0.1900
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.0753
    Cell Significance Index: -0.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD36B is a C/D box snoRNA, which is a subclass of small nucleolar RNAs that regulate RNA processing and modification. snoRNAs are known to bind to specific target RNAs, influencing their maturation, stability, and function. SNORD36B is specifically expressed in various cell types, including pericytes, cardiac endothelial cells, cardiac muscle myoblasts, and immune cells such as immature innate lymphoid cells. Its expression is also observed in fibroblasts of cardiac tissue, smooth muscle myoblasts, type A enteroendocrine cells, acinar cells, and neuronal receptor cells. **Pathways and Functions:** SNORD36B is involved in several cellular pathways, including RNA processing and cell differentiation. Its primary function is to regulate the maturation of ribosomal RNA (rRNA) by binding to specific target RNAs and influencing their processing. This process is essential for the assembly of ribosomes, which are responsible for protein synthesis. Additionally, SNORD36B has been implicated in the regulation of cell differentiation, particularly in the development of cardiac and immune cells. Its expression is also associated with the regulation of gene expression, influencing the transcriptional activity of specific genes. **Clinical Significance:** The dysregulation of SNORD36B has been linked to various diseases, including cardiovascular disorders and immune-related conditions. For instance, alterations in SNORD36B expression have been observed in patients with heart failure, arrhythmias, and cardiac hypertrophy. Additionally, SNORD36B has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Furthermore, its expression has been linked to the development of certain types of cancer, including leukemia and lymphoma. Understanding the role of SNORD36B in these diseases can provide valuable insights into the molecular mechanisms underlying their development and progression, ultimately leading to the development of novel therapeutic strategies. In conclusion, SNORD36B is a small nucleolar RNA that plays a crucial role in RNA processing and cell differentiation. Its expression is observed in various cell types, including those relevant to immunology, and its dysregulation has been linked to various diseases. Further research is necessary to fully elucidate the functions of SNORD36B and its role in human disease, but its significance as a potential therapeutic target is clear.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.