Details for: IGHV7 56

Gene ID: 28380

Symbol: IGHV7 56

Ensembl ID: ENSG00000253131

Description: immunoglobulin heavy variable 7-56 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0094
    Cell Significance Index: 0.0600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0060
    Cell Significance Index: -0.0600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0090
    Cell Significance Index: -0.1200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0128
    Cell Significance Index: -0.1500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0191
    Cell Significance Index: -0.3100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0212
    Cell Significance Index: -0.2400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0240
    Cell Significance Index: -0.2300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0273
    Cell Significance Index: -0.3600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0283
    Cell Significance Index: -0.2800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0289
    Cell Significance Index: -0.3400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0309
    Cell Significance Index: -0.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0327
    Cell Significance Index: -0.6000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0352
    Cell Significance Index: -0.3700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0392
    Cell Significance Index: -0.4200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0459
    Cell Significance Index: -0.4300
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0599
    Cell Significance Index: -0.5200
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0670
    Cell Significance Index: -0.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0686
    Cell Significance Index: -0.3700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0744
    Cell Significance Index: -0.8800
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1609
    Cell Significance Index: -1.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGHV7-56 is classified as a pseudogene, meaning it lacks the ability to encode a functional protein due to mutations or deletions that prevent it from undergoing proper splicing and translation. 2. **Wide expression:** IGHV7-56 is expressed in a variety of cell types, including B cells, CD8-positive T cells, alpha-beta T cells, megakaryocytes, plasma cells, natural killer cells, plasmablasts, double-negative thymocytes, double-positive thymocytes, mature alpha-beta T cells, CD14-positive classical monocytes, and CD16-negative classical monocytes. 3. **Variable expression levels:** The expression levels of IGHV7-56 vary significantly across different cell types, suggesting that this gene may play distinct roles in different contexts. **Pathways and Functions:** 1. **Regulation of immune responses:** IGHV7-56 may modulate immune responses by influencing the expression of other genes involved in immune activation and regulation. 2. **Cell differentiation and survival:** The pseudogene may contribute to the differentiation and survival of immune cells by regulating the expression of key transcription factors and signaling molecules. 3. **Antigen presentation:** IGHV7-56 may play a role in the presentation of antigens to T cells, influencing the development of immune responses. 4. **Cytokine regulation:** The pseudogene may regulate the expression of cytokines, which are essential for the coordination of immune responses. **Clinical Significance:** 1. **Immunodeficiency disorders:** Abnormalities in IGHV7-56 expression may contribute to the development of immunodeficiency disorders, such as autoimmune diseases and cancer. 2. **Cancer:** The pseudogene may be involved in the development and progression of certain cancers, including lymphomas and leukemias. 3. **Infectious diseases:** IGHV7-56 may play a role in the immune response to infections, influencing the efficacy of vaccination and treatment. 4. **Personalized medicine:** Further research on IGHV7-56 may provide insights into the development of personalized therapies tailored to individual patients' immune profiles. In conclusion, the IGHV7-56 gene, despite its pseudogene status, has been found to have significant roles in the immune system, influencing cell differentiation, survival, and function. Further research is needed to fully elucidate the mechanisms by which IGHV7-56 modulates immune responses and to explore its clinical significance in the context of immunodeficiency disorders, cancer, and infectious diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.