Details for: TRAJ56

Gene ID: 28699

Symbol: TRAJ56

Ensembl ID: ENSG00000211835

Description: T cell receptor alpha joining 56

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0405
    Cell Significance Index: 0.4600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.0030
    Cell Significance Index: 0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0008
    Cell Significance Index: 0.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0021
    Cell Significance Index: -0.0400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0069
    Cell Significance Index: -0.0800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0127
    Cell Significance Index: -0.1700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0152
    Cell Significance Index: -0.1700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0157
    Cell Significance Index: -0.1900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0167
    Cell Significance Index: -0.1600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0189
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0194
    Cell Significance Index: -0.1800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0236
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0248
    Cell Significance Index: -0.2500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0309
    Cell Significance Index: -0.1700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0417
    Cell Significance Index: -0.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **T cell receptor alpha joining 56**: TRAJ56 is a member of the TRAJ gene family, which encodes proteins that interact with the T cell receptor (TCR) complex. The TCR is a crucial component of T cells, responsible for recognizing and binding to specific antigens, thereby triggering an immune response. 2. **Alpha-beta T cell specificity**: TRAJ56 is specifically expressed in alpha-beta T cells, a subset of T cells that are central to the adaptive immune response. 3. **Widespread expression**: TRAJ56 is expressed in a diverse range of cell types, including CD8-positive, CD4-positive T cells, alpha-beta T cells, stromal cells, and even non-immune cells such as GABAergic cortical interneurons. 4. **Differential expression**: The expression of TRAJ56 varies across different cell types and developmental stages, suggesting a nuanced role in immune regulation. **Pathways and Functions:** 1. **T cell receptor signaling**: TRAJ56 interacts with the TCR complex, modulating the signaling pathways that regulate T cell activation, proliferation, and differentiation. 2. **Immune homeostasis**: TRAJ56 plays a crucial role in maintaining immune homeostasis by regulating the balance between T cell activation and tolerance. 3. **Thymic development**: TRAJ56 is expressed in alpha-beta T cells during thymic development, where it contributes to the selection and maturation of T cells. 4. **Regulation of immune responses**: TRAJ56 modulates the intensity and specificity of immune responses by regulating the activation and proliferation of T cells. **Clinical Significance:** 1. **Autoimmune diseases**: Dysregulation of TRAJ56 has been implicated in various autoimmune diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. 2. **Cancer immunotherapy**: TRAJ56 plays a critical role in cancer immunotherapy, where it modulates the activity of T cells to target and eliminate cancer cells. 3. **Immunodeficiency disorders**: Mutations in TRAJ56 have been associated with immunodeficiency disorders, highlighting the gene's importance in maintaining immune function. 4. **Neurological disorders**: TRAJ56's expression in GABAergic cortical interneurons suggests a potential role in neurological disorders, such as epilepsy and Alzheimer's disease. In conclusion, TRAJ56 is a gene of immense importance in the regulation of the immune system. Its intricate expression patterns and multifaceted role in immune homeostasis, thymic development, and immune response regulation underscore its clinical significance. Further research is necessary to fully elucidate the mechanisms by which TRAJ56 regulates immune function and to explore its potential as a therapeutic target in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.