Details for: MIR107

Gene ID: 406901

Symbol: MIR107

Ensembl ID: ENSG00000198997

Description: microRNA 107

Associated with

  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Extracellular space
    (GO:0005615)
  • Extracellular vesicle
    (GO:1903561)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of amyloid precursor protein catabolic process
    (GO:1902992)
  • Negative regulation of d-glucose import
    (GO:0046325)
  • Negative regulation of fat cell differentiation
    (GO:0045599)
  • Negative regulation of insulin receptor signaling pathway
    (GO:0046627)
  • Negative regulation of vascular endothelial growth factor production
    (GO:1904046)
  • Neuronal cell body
    (GO:0043025)
  • Positive regulation of gluconeogenesis
    (GO:0045722)
  • Positive regulation of necroptotic process
    (GO:0060545)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.0239
    Cell Significance Index: 0.2700
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.0152
    Cell Significance Index: 0.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0126
    Cell Significance Index: 0.3400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.0059
    Cell Significance Index: 0.0800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0024
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0003
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0026
    Cell Significance Index: -0.1300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0070
    Cell Significance Index: -0.0800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0072
    Cell Significance Index: -0.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0201
    Cell Significance Index: -0.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR107 is a 22-nucleotide long, single-stranded RNA molecule that is highly conserved across species, including humans. It is primarily expressed in neuronal and non-neuronal cells, including immune cells, smooth muscle cells, and fibroblasts. MIR107 is a negative regulator of various cellular processes, including insulin signaling, glucose import, and vascular endothelial growth factor production. Its expression is tightly regulated by various signaling pathways, including the insulin receptor signaling pathway and the RISC complex. **Pathways and Functions:** MIR107 is involved in several cellular pathways, including: 1. **Cellular response to hydrogen peroxide**: MIR107 modulates the expression of genes involved in oxidative stress response, protecting cells from damage caused by reactive oxygen species. 2. **Cellular response to insulin stimulus**: MIR107 inhibits insulin signaling, regulating glucose uptake and metabolism in cells. 3. **Extracellular space**: MIR107 is involved in the regulation of extracellular vesicle formation and function, influencing cell-to-cell communication. 4. **Mirna-mediated gene silencing by inhibition of translation**: MIR107 targets mRNAs for degradation or inhibition of translation, modulating protein expression and cellular function. 5. **Negative regulation of amyloid precursor protein catabolic process**: MIR107 inhibits the expression of genes involved in amyloid precursor protein degradation, potentially contributing to Alzheimer's disease pathogenesis. 6. **Negative regulation of fat cell differentiation**: MIR107 regulates the expression of genes involved in adipogenesis, influencing fat cell development and metabolism. 7. **Negative regulation of glucose import**: MIR107 inhibits glucose uptake in cells, regulating glucose metabolism and energy homeostasis. 8. **Negative regulation of insulin receptor signaling pathway**: MIR107 modulates insulin signaling, influencing glucose uptake and metabolism in cells. 9. **Negative regulation of vascular endothelial growth factor production**: MIR107 inhibits the expression of genes involved in angiogenesis, regulating vascular endothelial growth factor production. 10. **Positive regulation of gluconeogenesis**: MIR107 regulates the expression of genes involved in gluconeogenesis, influencing glucose production and metabolism in cells. 11. **Positive regulation of necroptotic process**: MIR107 modulates the expression of genes involved in necroptosis, influencing cell death and apoptosis. **Clinical Significance:** MIR107 has been implicated in various diseases, including: 1. **Alzheimer's disease**: MIR107 has been shown to be downregulated in Alzheimer's disease patients, contributing to amyloid precursor protein accumulation and neurodegeneration. 2. **Diabetes**: MIR107 has been implicated in glucose metabolism and insulin signaling, influencing the development of type 2 diabetes. 3. **Cardiovascular disease**: MIR107 has been shown to regulate vascular endothelial growth factor production, influencing angiogenesis and cardiovascular disease pathogenesis. 4. **Cancer**: MIR107 has been implicated in cancer development and progression, regulating cell growth, invasion, and metastasis. In conclusion, microRNA-107 plays a critical role in regulating various cellular processes, including immune response, cellular homeostasis, and disease pathogenesis. Its dysregulation has been implicated in various diseases, highlighting the potential of MIR107 as a therapeutic target for disease treatment and prevention.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.