Details for: DEFB105B

Gene ID: 504180

Symbol: DEFB105B

Ensembl ID: ENSG00000186599

Description: defensin beta 105B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.35
    Marker Score: 2411
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.22
    Marker Score: 2398
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 2.47
    Marker Score: 1969
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.27
    Marker Score: 2412
  • Cell Name: macrophage (CL0000235)
    Fold Change: 2.16
    Marker Score: 2406
  • Cell Name: brush cell (CL0002204)
    Fold Change: 1.83
    Marker Score: 1668
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.74
    Marker Score: 2402
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.48
    Marker Score: 2397
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.44
    Marker Score: 9556
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.16
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.08
    Marker Score: 3222
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.04
    Marker Score: 6321
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30330
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4612

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Other Information

**Key Characteristics:** 1. **Antimicrobial properties:** Defensin Beta 105B has been shown to exhibit antimicrobial activity against a range of microorganisms, including bacteria, viruses, and fungi. 2. **Structure:** DEF105B belongs to the beta-defensin family, characterized by a four-cysteine motif and a unique conformation that allows it to interact with target membranes. 3. **Expression pattern:** DEF105B is expressed in various cell types, including erythrocytes, megakaryocytes, and intestinal epithelial cells, suggesting its involvement in different aspects of immune defense. 4. **Cellular localization:** DEF105B is primarily found in the extracellular environment, where it can interact with target membranes and exert its antimicrobial effects. **Pathways and Functions:** 1. **Antimicrobial peptide pathways:** DEF105B is involved in the antimicrobial peptide (AMP) pathway, which plays a crucial role in the innate immune response against invading pathogens. 2. **Innate immune response:** DEF105B is a key player in the innate immune response, providing the first line of defense against invading pathogens. 3. **Extracellular matrix interactions:** DEF105B interacts with the extracellular matrix, modulating its structure and function to facilitate immune cell migration and tissue repair. 4. **Cell signaling pathways:** DEF105B modulates cell signaling pathways, including the NF-κB and MAPK pathways, to regulate immune responses and inflammation. **Clinical Significance:** 1. **Infectious diseases:** DEF105B has been implicated in the pathogenesis of various infectious diseases, including sepsis, pneumonia, and urinary tract infections. 2. **Cancer:** DEF105B has been shown to have anti-tumor effects, inhibiting cancer cell growth and migration. 3. **Neurological disorders:** DEF105B has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and multiple sclerosis. 4. **Therapeutic potential:** DEF105B has been identified as a potential therapeutic target for infectious diseases, cancer, and neurological disorders, highlighting its potential as a novel treatment option. In conclusion, Defensin Beta 105B (DEFB105B) is a key player in the innate immune response, providing the first line of defense against invading pathogens. Its antimicrobial properties, structure, and expression pattern make it an attractive target for therapeutic intervention in infectious diseases, cancer, and neurological disorders. Further research is needed to fully elucidate the molecular mechanisms and clinical significance of DEF105B, but its potential as a therapeutic agent is undeniable.

Genular Protein ID: 2451881789

Symbol: B2RU30_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RU30

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 Pfam 2 RefSeq 1 RuleBase 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 78
  • Mass: 8923
  • Checksum: A0B07DDC7CF2C7DE
  • Sequence:
    • MALNRKTFYF LFAMFFILVQ LPSGCQAGLD FSQPFPSGEF AVCESCKLGR GKCRKECLEN 
EKPDGNCRLN FLCCRQRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.