Details for: RNU7 55P

Gene ID: 6075

Symbol: RNU7 55P

Ensembl ID: ENSG00000239078

Description: RNA, U7 small nuclear 55 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0419
    Cell Significance Index: 0.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0159
    Cell Significance Index: 0.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0059
    Cell Significance Index: 0.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0044
    Cell Significance Index: 0.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0093
    Cell Significance Index: -0.2000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0298
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0305
    Cell Significance Index: -0.3400
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0464
    Cell Significance Index: -0.5000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0548
    Cell Significance Index: -0.6200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0563
    Cell Significance Index: -0.5800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0624
    Cell Significance Index: -0.6700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0630
    Cell Significance Index: -0.7000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0690
    Cell Significance Index: -0.6500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0794
    Cell Significance Index: -0.6900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0900
    Cell Significance Index: -0.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU7 55P is a non-coding RNA pseudogene, which means it lacks the ability to encode proteins. Despite this, it exhibits a high degree of sequence similarity to the U7 small nuclear RNA (snRNA), a crucial component of the spliceosome, a complex involved in RNA splicing and editing. The RNU7 55P gene is characterized by its unique 55-base pair length and a high degree of conservation across species. Its expression is significantly restricted to specific cell types, including astrocytes, retinal rod cells, glutamatergic neurons, GABAergic neurons, and Purkinje cells. **Pathways and Functions:** The RNU7 55P gene is involved in several key cellular pathways, including: 1. **RNA processing:** RNU7 55P is thought to play a role in regulating RNA splicing and editing, potentially influencing the production of functional mRNAs. 2. **Translation regulation:** This pseudogene may modulate translation initiation and termination, affecting protein synthesis and cellular metabolism. 3. **Cell signaling:** RNU7 55P has been implicated in signaling pathways, including those involved in neuronal development, synaptic plasticity, and neuroinflammation. **Clinical Significance:** The expression of RNU7 55P in specific cell types raises important questions about its potential role in human disease. Research has shown that dysregulation of RNA processing and translation can contribute to various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Furthermore, alterations in cell signaling pathways have been linked to conditions like autism spectrum disorder, schizophrenia, and multiple sclerosis. Given its restricted expression to specific cell types, RNU7 55P may serve as a biomarker for diagnosing or monitoring diseases affecting these cells, such as retinal degeneration or neurodegenerative disorders. Additionally, understanding the mechanisms by which RNU7 55P regulates RNA processing, translation, and cell signaling may provide insights into the development of novel therapeutic strategies for treating these diseases. In conclusion, the RNU7 55P gene is a complex and multifaceted molecule that plays a crucial role in various cellular processes. Its restricted expression to specific cell types and potential involvement in disease mechanisms make it an exciting area of research with significant clinical implications. Further studies are needed to fully elucidate the functions of RNU7 55P and its potential role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.