Details for: ADGRG7

Gene ID: 84873

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ADGRG7

Ensembl ID: ENSG00000144820

Description: adhesion G protein-coupled receptor G7

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • midzonal region hepatocyte CL0019028
    CSI 4.37
    rCSI 10.25%
    PRS 93.23
  • goblet cell CL0000160
    CSI 2.8
    rCSI 2.65%
    PRS 94.43
  • BEST4+ enteroycte CL4030026
    CSI 2.74
    rCSI 3.4%
    PRS 95.2
  • intestine goblet cell CL0019031
    CSI 2.5
    rCSI 2.22%
    PRS 94.46
  • stem cell CL0000034
    CSI 2.46
    rCSI 2.37%
    PRS 94.13
  • M cell of gut CL0000682
    CSI 2.33
    rCSI 2.47%
    PRS 96.58
  • intestinal epithelial cell CL0002563
    CSI 2.09
    rCSI 2.18%
    PRS 94.5
  • colonocyte CL1000347
    CSI 1.94
    rCSI 2.78%
    PRS 94.39
  • small intestine goblet cell CL1000495
    CSI 1.76
    rCSI 3.85%
    PRS 96.64
  • enterocyte CL0000584
    CSI 1.73
    rCSI 2.8%
    PRS 93.42
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.4
    rCSI 3.77%
    PRS 96.69
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.38
    rCSI 5.89%
    PRS 96.23

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ADGRG7](/details-gene/84873), or Adhesion G Protein-Coupled Receptor G7, is a protein-coding gene located on chromosome 3. As a member of the adhesion G protein-coupled receptor (GPCR) family, it is characterized by a large extracellular N-terminus and is believed to play a role in cell signaling and adhesion [Link](https://doi.org/10.1124/pr.114.009647). **Overall**, expression data indicate that [ADGRG7](/details-gene/84873) is a highly significant marker for specialized epithelial cells of the digestive system, with its most prominent expression observed in [midzonal region hepatocyte](/details-cell/CL0019028)s in the liver and various secretory and stem cell populations within the intestine, such as [goblet cell](/details-cell/CL0000160)s. This suggests a primary function related to epithelial homeostasis, cell-cell communication, and metabolic regulation within these tissues. ## Cellular Roles and Expression Landscape The expression profile of [ADGRG7](/details-gene/84873) reveals a highly specific role within the gastrointestinal tract and liver. **Overall**, its most significant expression is in [midzonal region hepatocyte](/details-cell/CL0019028)s (CSI: 4.37), pointing to a potential function in the metabolic zonation and signaling within the liver lobule. Beyond the liver, [ADGRG7](/details-gene/84873) demonstrates a strong association with the intestinal epithelium. It is a key marker for secretory cells, including [goblet cell](/details-cell/CL0000160)s (CSI: 2.80) of both the small and large intestine, and specialized absorptive cells like [BEST4+ enteroycte](/details-cell/CL4030026) (CSI: 2.74). Furthermore, its significance in [stem cell](/details-cell/CL0000034) (CSI: 2.46) and specifically [intestinal crypt stem cell of small intestine](/details-cell/CL0009017) (CSI: 1.40) suggests a role in the maintenance and differentiation of the intestinal lining. Its consistent presence in general populations like [intestinal epithelial cell](/details-cell/CL0002563) (CSI: 2.09) and [colonocyte](/details-cell/CL1000347) (CSI: 1.94) reinforces its broad importance in gut epithelial biology. The collective data strongly support a function for [ADGRG7](/details-gene/84873) in mediating cell-cell or cell-matrix interactions and signaling events that govern the complex architecture and function of digestive tissues. ## Pathways and Molecular Function Functionally, [ADGRG7](/details-gene/84873) is annotated as a G protein-coupled receptor localized to the [plasma membrane](/details-cell/GO:0005886). Its primary molecular function is [G protein-coupled receptor activity](/details-cell/GO:0004930), enabling it to participate in a variety of signaling cascades. Specifically, it is linked to the [G protein-coupled receptor signaling pathway](/details-cell/GO:0007186) and the [adenylate cyclase-activating g protein-coupled receptor signaling pathway](/details-cell/GO:0007189). This functional profile is consistent with its role as a sensor on the surface of epithelial cells in the gut and liver, where it likely responds to extracellular cues to modulate intracellular processes related to cell fate, metabolism, and barrier integrity. ## Research Directions The specific expression pattern of [ADGRG7](/details-gene/84873) in key homeostatic and regenerative cell populations of the gut and liver provides a foundation for several compelling research avenues, particularly in the context of inflammatory diseases and cancer. **Proposed Hypotheses:** 1. Given its high significance in both [intestinal crypt stem cell of small intestine](/details-cell/CL0009017) and their differentiated secretory progeny like [goblet cell](/details-cell/CL0000160)s, [ADGRG7](/details-gene/84873) may function as a critical regulator of cell fate decisions, guiding the differentiation of intestinal stem cells towards secretory lineages in response to luminal or microbial signals. 2. The top-ranking expression of [ADGRG7](/details-gene/84873) in [midzonal region hepatocyte](/details-cell/CL0019028)s suggests it plays a role in establishing or maintaining liver zonation. It may act as a sensor for specific components in the sinusoidal blood, activating signaling pathways that control the unique metabolic gene expression programs of this hepatic zone. **Experimental Approach:** To test the hypothesis regarding its role in intestinal stem cell differentiation, an ideal model would be murine or human intestinal organoids. CRISPR-Cas9-mediated knockout of [ADGRG7](/details-gene/84873) in these organoids would allow for a direct assessment of its function. Single-cell RNA sequencing (scRNA-seq) of control versus knockout organoids could then be performed to quantify changes in the proportions of different epithelial cell types (e.g., stem cells, enterocytes, goblet cells, Paneth cells) and to analyze shifts in differentiation trajectories. This would reveal whether loss of [ADGRG7](/details-gene/84873) skews differentiation away from or towards the secretory lineage. **Therapeutic Potential:** As a cell-surface GPCR, [ADGRG7](/details-gene/84873) is a highly druggable target. Its restricted expression to gastrointestinal and liver epithelia makes it an attractive candidate for therapies targeting diseases of these organs, such as inflammatory bowel disease (IBD), colorectal cancer, or non-alcoholic fatty liver disease (NAFLD), with potentially minimal off-target effects. Depending on its specific role in a disease context, both small molecule agonists and antagonists could be developed. For instance, if its signaling promotes epithelial barrier repair, an agonist could be therapeutic in IBD. Conversely, if it promotes proliferation in colorectal cancer, an antagonist or an antibody-drug conjugate targeting [ADGRG7](/details-gene/84873)-expressing tumor cells would be a viable strategy.

Genular Protein ID: 4009255521

Symbol: AGRG7_HUMAN

Name: G-protein coupled receptor 128

UniProtKB Accession Codes:

Q96K78 Q14D94 Q86SQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12565841

Title: There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.

PubMed ID: 12565841

DOI: 10.1016/s0006-291x(03)00026-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25713288

Title: International union of basic and clinical pharmacology. XCIV. Adhesion G protein-coupled receptors.

PubMed ID: 25713288

DOI: 10.1124/pr.114.009647

Sequence Information:

  • Length: 797
  • Mass: 88909
  • Checksum: D6CAAA78AC0E4679
  • Sequence:
    • MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE FCRNGGTWEN 
GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP SLQTCGKDTP NAGNPMAVRL 
CSLSLYGEIE LQKVTIGNCN ENLETLEKQV KDVTAPLNNI SSEVQILTSD ANKLTAENIT 
SATRVVGQIF NTSRNASPEA KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET 
YSLSLGNQSV VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN 
PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS KTDENEQDQS 
ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK DKGTDGFLRC RCNHTTNFAV 
LMTFKKDYQY PKSLDILSNV GCALSVTGLA LTVIFQIVTR KVRKTSVTWV LVNLCISMLI 
FNLLFVFGIE NSNKNLQTSD GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT 
FTWNALSAAQ LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE 
LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV LWKNNQNLTS 
TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV FSYIFCLFNT TQGLQIFILY 
TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV TRPRLRVKMY NFLRSLPTLH ERFRLLETSP 
STEEITLSES DNAKESI

Genular Protein ID: 2571203400

Symbol: E9PHI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PHI0

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 502
  • Mass: 57425
  • Checksum: 2C3289FE13778749
  • Sequence:
    • MPVKMLFKEL LLLLMMMPLQ HYTKTCGFVV YQNDKLFQSK TFTAKSDFSQ KIISSKTDEN 
EQDQSASVDM VFSPKYNQKE FQLYSYACVY WNLSAKDWDT YGCQKDKGTD GFLRCRCNHT 
TNFAVLMTFK KDYQYPKSLD ILSNVGCALS VTGLALTVIF QIVTRKVRKT SVTWVLVNLC 
ISMLIFNLLF VFGIENSNKN LQTSDGDINN IDFDNNDIPR TDTINIPNPM CTAIAALLHY 
FLLVTFTWNA LSAAQLYYLL IRTMKPLPRH FILFISLIGW GVPAIVVAIT VGVIYSQNGN 
NPQWELDYRQ EKICWLAIPE PNGVIKSPLL WSFIVPVTII LISNVVMFIT ISIKVLWKNN 
QNLTSTKKVS SMKKIVSTLS VAVVFGITWI LAYLMLVNDD SIRIVFSYIF CLFNTTQGLQ 
IFILYTVRTK VFQSEASKVL MLLSSIGRRK SLPSVTRPRL RVKMYNFLRS LPTLHERFRL 
LETSPSTEEI TLSESDNAKE SI

Genular Protein ID: 900225871

Symbol: Q6ZMH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZMH4

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 7 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 560
  • Mass: 63269
  • Checksum: 5C77212300B275BE
  • Sequence:
    • METYSLSLGN QSVVEPNIAI QSANFSSENA VGPSNVRFSV QKGASSSLVS SSTFIHTNVD 
GLNPDAQTEL QVLLNMTKNY TKTCGFVVYQ NDKLFQSKTF TAKSDFSQKI ISSKTDENEQ 
DQSASVDMVF SPKYNQKEFQ LYSYACVYWN LSAKDWDTYG CQKDKGTDGF LRCRCNHTTN 
FAVLMTFRKD YQYPKSLDIL SNVGCALSVT GLALTVIFQI VTRKVRKTSV TWVLVNLCIS 
MLIFNLLFVF GIENSNKNLQ TSDGDINNID FDNNDIPRTD TINIPNPMCT AIAALLHYFL 
LVTFTWNALS AAQLYYLLIR TMKPLPRHFI LFISLIGWGV PAIVVAITVG VIYSQNGNNP 
QWELDYRQEK ICWLAIPEPN GVIKSPLLWS FIVPVTIILI SNVVMFITIS IKVLWKNNQN 
LTSTKKVSSM KKIVSTLSVA VVFGITWILA YLMLVNDDSI RIVFSYIFCL FNTTQGLQIF 
ILYTVRTKVF QSEASKVLML LSSIGRRKSL PSVTRPRLRV KMYNFLRSLP TLHERFRLLE 
TSPSTEEITL SESDNAKESI

Genular Protein ID: 1670542352

Symbol: B7Z303_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z303

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 7 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 502
  • Mass: 57407
  • Checksum: 95F049FF07745349
  • Sequence:
    • MPVKMLFKEL LLLLMMMPLQ HYTKTCGFVV YQNDKLFQSK TFTAKSDFSQ KIISSKTDEN 
EQDQSASVDM VFSPKYNQKE FQLYSYACVY WNLSAKDWDT YGCQKDKGTD GFLRCRCNHT 
TNFAVLITFK KDYQYPKSLD ILSNVGCALS VTGLALTVIF QIVTRKVRKT SVTWVLVNLC 
ISMLIFNLLF VFGIENSNKN LQTSDGDINN IDFDNNDIPR TDTINIPNPM CTAIAALLHY 
FLLVTFTWNA LSAAQLYYLL IRTMKPLPRH FILFISLIGW GVPAIVVAIT VGVIYSQNGN 
NPQWELDYRQ EKICWLAIPE PNGVIKSPLL WSFIVPVTII LISNVVMFIT ISIKVLWKNN 
QNLTSTKKVS SMKKIVSTLS VAVVFGITWI LAYLMLVNDD SIRIVFSYIF CLFNTTQGLQ 
IFILYTVRTK VFQSEASKVL MLLSSIGRRK SLPSVTRPRL RVKMYNFLRS LPTLHERFRL 
LETSPSTEEI TLSESDNAKE SI