Details for: OR7E4P

Gene ID: 8585

Symbol: OR7E4P

Ensembl ID: ENSG00000255261

Description: olfactory receptor family 7 subfamily E member 4 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0716
    Cell Significance Index: 1.7900
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0304
    Cell Significance Index: 0.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0037
    Cell Significance Index: 0.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0055
    Cell Significance Index: -0.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0063
    Cell Significance Index: -0.1400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0070
    Cell Significance Index: -0.1400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0121
    Cell Significance Index: -0.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0124
    Cell Significance Index: -0.1300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0134
    Cell Significance Index: -0.1700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0137
    Cell Significance Index: -0.1200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0143
    Cell Significance Index: -0.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0167
    Cell Significance Index: -0.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** OR7E4P is a pseudogene, which means it has undergone mutations that render it non-functional or non-essential for the production of a protein. This characteristic raises questions about the gene's evolutionary history and its relevance to the immune system. 2. **Expression in stromal cells and classical monocytes:** OR7E4P is significantly expressed in stromal cells and classical monocytes, two cell types that play critical roles in maintaining tissue homeostasis and regulating immune responses. 3. **Lack of functional protein:** The pseudogene status of OR7E4P implies that it does not produce a functional protein, which could be a result of various factors, including mutations, gene regulation, or selection pressures. 4. **Evolutionary conservation:** Despite being a pseudogene, OR7E4P shows signs of evolutionary conservation, suggesting that it may have played a role in the immune system's development or function in the past. **Pathways and Functions:** 1. **Immune regulation:** OR7E4P's expression in stromal cells and classical monocytes implies that it may be involved in regulating immune responses, possibly modulating the activity of these cells. 2. **Cellular signaling:** The pseudogene's presence in these cell types may also suggest involvement in cellular signaling pathways, influencing the behavior of immune cells and their interactions with the surrounding tissue. 3. **Gene regulation:** OR7E4P may act as a decoy or a regulatory element, influencing the expression of nearby genes or the activity of transcription factors involved in immune cell development and function. 4. **Evolutionary conservation:** The conservation of OR7E4P across species may indicate that it has played a role in the evolution of the immune system, possibly as a regulatory element or a gene involved in immune cell development. **Clinical Significance:** 1. **Immunological disorders:** The potential involvement of OR7E4P in immune regulation and cellular signaling pathways may have implications for the development of immunological disorders, such as autoimmune diseases or immunodeficiency syndromes. 2. **Cancer and tumor microenvironment:** The expression of OR7E4P in stromal cells and classical monocytes may also be relevant to cancer biology, particularly in the context of tumor microenvironments and immune evasion. 3. **Vaccine development:** Understanding the functions and regulatory mechanisms of OR7E4P may provide insights into the development of novel vaccine strategies that target specific immune cell populations or regulatory pathways. 4. **Evolutionary medicine:** The study of OR7E4P may also shed light on the evolution of the human immune system and the emergence of novel immune-related diseases, highlighting the importance of considering evolutionary factors in disease research. In conclusion, the OR7E4P gene, despite being a pseudogene, holds significant promise for our understanding of immune regulation and cellular signaling pathways. Further research is necessary to unravel the mysteries surrounding this enigmatic gene and its potential implications for human health.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.