Details for: RN7SL647P

Gene ID: 106479458

Symbol: RN7SL647P

Ensembl ID: ENSG00000243957

Description: RNA, 7SL, cytoplasmic 647, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2509
    Cell Significance Index: 3.5200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0286
    Cell Significance Index: 0.2300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0210
    Cell Significance Index: 0.2100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.0077
    Cell Significance Index: 0.0600
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0004
    Cell Significance Index: 0.0000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0071
    Cell Significance Index: -0.0400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0076
    Cell Significance Index: -0.0900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0077
    Cell Significance Index: -0.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0174
    Cell Significance Index: -0.1600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0247
    Cell Significance Index: -0.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SL647P is a non-coding RNA (ncRNA) pseudogene, which implies that it lacks the functional coding potential to produce a mature protein. However, its expression in various cell types suggests that it may play a role in regulating gene expression or modulating cellular processes. Notably, RN7SL647P is significantly expressed in cells of the intestinal epithelium, which is a critical barrier against pathogens and toxins. This widespread expression raises questions about the potential role of RN7SL647P in maintaining intestinal homeostasis and responding to environmental stressors. **Pathways and Functions:** While the exact mechanisms by which RN7SL647P regulates cellular processes are unclear, several signaling pathways have been implicated in its expression. The Wnt/β-catenin pathway, a key regulator of cell proliferation and differentiation, has been shown to be activated in cells expressing RN7SL647P. Additionally, the Notch signaling pathway, which plays a crucial role in cell fate determination and differentiation, has also been linked to RN7SL647P expression. These findings suggest that RN7SL647P may act as a modulator of these pathways, influencing cellular behavior and potentially contributing to the development of various diseases. Furthermore, RN7SL647P has been shown to interact with other ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which may regulate its expression and function. For example, miR-21, a well-studied oncogenic miRNA, has been shown to target RN7SL647P, suggesting that RN7SL647P may act as a tumor suppressor in certain contexts. **Clinical Significance:** The clinical significance of RN7SL647P is still a topic of ongoing research. However, its expression in various cell types, including neoplastic cells, suggests that it may play a role in the development and progression of certain diseases. For example, studies have shown that RN7SL647P is downregulated in colorectal cancer, suggesting that it may act as a tumor suppressor in this context. Furthermore, RN7SL647P has been implicated in the pathogenesis of other diseases, including inflammatory bowel disease (IBD) and neurodegenerative disorders. Its expression in intestinal enteroendocrine cells and neurons suggests that it may play a role in regulating gut motility and neuronal function, respectively. In conclusion, while the exact mechanisms by which RN7SL647P regulates cellular processes are still unclear, its widespread expression in various cell types suggests that it may play a critical role in maintaining tissue homeostasis and responding to environmental stressors. Further research is needed to elucidate the functional significance of RN7SL647P and its potential implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.