Details for: DEFB106A

Gene ID: 245909

Symbol: DEFB106A

Ensembl ID: ENSG00000186579

Description: defensin beta 106A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.36
    Marker Score: 2413
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 2.47
    Marker Score: 1969
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.27
    Marker Score: 2408
  • Cell Name: macrophage (CL0000235)
    Fold Change: 2.16
    Marker Score: 2404
  • Cell Name: brush cell (CL0002204)
    Fold Change: 1.86
    Marker Score: 1699
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.75
    Marker Score: 2410
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.4
    Marker Score: 2413
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.16
    Marker Score: 2410
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7250
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.97
    Marker Score: 1573
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.94
    Marker Score: 29141
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4612
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8
    Marker Score: 4846
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.63
    Marker Score: 2577.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.04
    Marker Score: 2413

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Other Information

**Key Characteristics** Defensin Beta 106A exhibits several key characteristics that contribute to its antimicrobial and immunomodulatory functions: 1. **Antimicrobial activity**: Defensin Beta 106A displays strong antimicrobial activity against gram-positive and gram-negative bacteria, fungi, and viruses, making it a potent component of the innate immune response. 2. **Structural features**: The peptide contains a characteristic alpha-helix structure, which is essential for its antimicrobial activity and ability to interact with target membranes. 3. **Cell surface expression**: Defensin Beta 106A is primarily expressed on the surface of cells, where it can interact with pathogens and initiate an immune response. 4. **Post-translational modifications**: The peptide undergoes post-translational modifications, such as glycosylation and phosphorylation, which may influence its function and stability. **Pathways and Functions** Defensin Beta 106A participates in several key pathways and functions, including: 1. **Antifungal innate immune response**: Defensin Beta 106A plays a crucial role in the innate immune response against fungal pathogens, such as Candida albicans. 2. **Antimicrobial peptides**: As a member of the defensin family, Defensin Beta 106A contributes to the antimicrobial activity of the innate immune response, helping to protect against a wide range of pathogens. 3. **Immune system regulation**: Defensin Beta 106A may also regulate immune system function, modulating the activity of immune cells and influencing the development of immune responses. 4. **Cell signaling**: The peptide may interact with cell surface receptors, such as CCR2, influencing cell signaling pathways and modulating immune responses. **Clinical Significance** Defensin Beta 106A has significant clinical implications, including: 1. **Antimicrobial therapy**: Defensin Beta 106A may be used as a therapeutic agent against bacterial and fungal infections, particularly those resistant to conventional antibiotics. 2. **Immunodeficiency disorders**: Defensin Beta 106A deficiency may contribute to immunodeficiency disorders, such as recurrent infections and impaired immune responses. 3. **Cancer therapy**: The peptide's ability to modulate immune responses and regulate cell signaling may make it a potential therapeutic agent in cancer treatment. 4. **Vaccine development**: Defensin Beta 106A may be used as a component of vaccines to enhance immune responses against specific pathogens. In conclusion, Defensin Beta 106A is a critical component of the innate immune response, providing a potent defense against a wide range of pathogens. Its clinical significance is significant, with potential applications in antimicrobial therapy, immunodeficiency disorders, cancer therapy, and vaccine development. Further research is needed to fully understand the functions and therapeutic potential of this peptide.

Genular Protein ID: 1240879425

Symbol: D106A_HUMAN

Name: Beta-defensin 106

UniProtKB Accession Codes:

Q8N104 Q2NKR0 Q496I8

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID 1 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CTD 2 DMDM 1 DNASU 1 DisGeNET 2 EMBL 10 Ensembl 6 GO 10 GeneCards 2 GeneTree 1 GeneWiki 1 Genevisible 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 InterPro 1 KEGG 2 MANE-Select 2 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 3 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 2 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11854508

Title: Discovery of five conserved beta-defensin gene clusters using a computational search strategy.

PubMed ID: 11854508

DOI: 10.1073/pnas.042692699

PubMed ID: 12193721

Title: Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.

PubMed ID: 12193721

DOI: 10.4049/jimmunol.169.5.2516

PubMed ID: 12600824

Title: ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes.

PubMed ID: 12600824

DOI: 10.1165/rcmb.2002-0205oc

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12734011

Title: Duplication and selection in the evolution of primate beta-defensin genes.

PubMed ID: 12734011

DOI: 10.1186/gb-2003-4-5-r31

PubMed ID: 23938203

Title: Structural basis for the interaction of human beta-defensin 6 and its putative chemokine receptor CCR2 and breast cancer microvesicles.

PubMed ID: 23938203

DOI: 10.1016/j.jmb.2013.08.001

Sequence Information:

  • Length: 65
  • Mass: 7369
  • Checksum: 9D1C89BB0041E02D
  • Sequence:
    • MRTFLFLFAV LFFLTPAKNA FFDEKCNKLK GTCKNNCGKN EELIALCQKS LKCCRTIQPC 
GSIID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.