Details for: SNORA64

Gene ID: 26784

Symbol: SNORA64

Ensembl ID: ENSG00000207405

Description: small nucleolar RNA, H/ACA box 64

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0013
    Cell Significance Index: -0.3700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0074
    Cell Significance Index: -0.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0081
    Cell Significance Index: -0.4200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0089
    Cell Significance Index: -0.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0142
    Cell Significance Index: -0.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0190
    Cell Significance Index: -0.2400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0276
    Cell Significance Index: -0.3600
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0288
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0298
    Cell Significance Index: -0.3200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0306
    Cell Significance Index: -0.3500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0315
    Cell Significance Index: -0.3600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0327
    Cell Significance Index: -0.3900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0345
    Cell Significance Index: -0.4200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0348
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0349
    Cell Significance Index: -0.4200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0426
    Cell Significance Index: -0.4200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0451
    Cell Significance Index: -0.4200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0477
    Cell Significance Index: -0.4200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0480
    Cell Significance Index: -0.4200
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0788
    Cell Significance Index: -0.3800
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.1506
    Cell Significance Index: -0.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORA64, with an Ensembl ID of ENSG00000207405, is a small nucleolar RNA that belongs to the H/ACA box family. This family of sRNAs is known for their involvement in RNA processing, particularly in the modification of ribosomal RNA (rRNA) and other small RNAs. SNORA64 is significantly expressed in various cell types, including pericytes, cardiac endothelial cells, cardiac muscle myoblasts, and lymphoid lineage-restricted progenitor cells. Its expression is also notable in fibroblasts of cardiac tissue, type A enteroendocrine cells, smooth muscle myoblasts, neuronal receptor cells, and acinar cells. **Pathways and Functions:** SNORA64 is involved in several key pathways, including nucleolus, protein binding, and RNA processing. In the nucleolus, SNORA64 plays a crucial role in the modification of rRNA, which is essential for ribosome biogenesis and function. Additionally, SNORA64 interacts with proteins involved in RNA processing, such as the nucleolar protein Nop1, to regulate the expression of genes involved in cellular differentiation and development. The functions of SNORA64 can be broadly categorized into two main areas: RNA processing and cellular differentiation. In RNA processing, SNORA64 is involved in the modification of rRNA and other small RNAs, which is essential for maintaining cellular homeostasis. In cellular differentiation, SNORA64 plays a crucial role in regulating the expression of genes involved in cell fate decisions, such as the development of cardiac muscle cells. **Clinical Significance:** The clinical significance of SNORA64 is an area of ongoing research. However, its expression in various cell types and its involvement in RNA processing and cellular differentiation suggest that it may play a role in various diseases, including cardiovascular disease, cancer, and neurological disorders. For example, alterations in SNORA64 expression have been associated with cardiac remodeling and hypertrophy, suggesting that it may be a potential therapeutic target for the treatment of cardiovascular disease. Furthermore, SNORA64's involvement in RNA processing and cellular differentiation suggests that it may be a potential biomarker for disease diagnosis and prognosis. For example, changes in SNORA64 expression may be used to diagnose cardiac disease or predict the risk of disease progression. In conclusion, SNORA64 is a small nucleolar RNA that plays a crucial role in RNA processing and cellular differentiation. Its involvement in various pathways, including nucleolus, protein binding, and RNA processing, highlights its importance in maintaining cellular homeostasis. Its clinical significance, particularly in the context of cardiovascular disease, cancer, and neurological disorders, underscores the need for further research into the role of SNORA64 in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.