Details for: SNORD48

Gene ID: 26801

Symbol: SNORD48

Ensembl ID: ENSG00000201823

Description: small nucleolar RNA, C/D box 48

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0199
    Cell Significance Index: 0.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0096
    Cell Significance Index: 0.1200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0082
    Cell Significance Index: 0.0700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0038
    Cell Significance Index: -0.0300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0061
    Cell Significance Index: -0.0500
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0066
    Cell Significance Index: -0.0300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0079
    Cell Significance Index: -0.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD48 is a 48-base pair C/D box snoRNA, characterized by its unique nucleotide sequence and structural features. The snoRNA's primary function involves the modification of ribosomal RNA (rRNA) and other small RNAs, which is essential for the proper assembly and maturation of ribosomes. The snoRNA's presence is often associated with the nucleolus, a region within the nucleus responsible for ribosome biogenesis. The widespread expression of SNORD48 across diverse cell types highlights its potential role in regulating cellular function and responding to environmental cues. **Pathways and Functions:** The molecular pathways and functions of SNORD48 are multifaceted and far-reaching. As a snoRNA, SNORD48 plays a crucial role in the post-transcriptional modification of rRNA, which is essential for ribosome biogenesis and function. The snoRNA's involvement in RNA processing pathways has significant implications for the regulation of protein synthesis, cell growth, and differentiation. Furthermore, SNORD48's presence in neurons suggests its potential role in neuronal function and plasticity, including the regulation of synaptic transmission and neuronal survival. **Clinical Significance:** The clinical significance of SNORD48 is an area of active research, with potential implications for the diagnosis and treatment of various diseases. The snoRNA's widespread expression across diverse cell types underscores its potential role in regulating cellular homeostasis and responding to environmental cues. Aberrant expression of SNORD48 has been implicated in several diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. The development of novel therapeutic strategies targeting SNORD48 may offer new avenues for the treatment of these conditions. Furthermore, the study of SNORD48's molecular mechanisms and cellular functions may provide valuable insights into the regulation of cellular homeostasis and the development of novel therapeutic approaches. In conclusion, SNORD48 is a small nucleolar RNA with far-reaching implications for cellular function and regulation. The snoRNA's widespread expression across diverse cell types underscores its potential role in maintaining cellular homeostasis and responding to environmental cues. Further research is necessary to fully elucidate the molecular mechanisms and clinical significance of SNORD48, but the available evidence suggests that this snoRNA is a molecule of great interest and potential therapeutic value.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.