Details for: SNORD32A

Gene ID: 26819

Symbol: SNORD32A

Ensembl ID: ENSG00000201675

Description: small nucleolar RNA, C/D box 32A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8190
    Cell Significance Index: 8.4800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.6123
    Cell Significance Index: 7.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0027
    Cell Significance Index: 0.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0012
    Cell Significance Index: -0.0600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0052
    Cell Significance Index: -0.0700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0058
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0064
    Cell Significance Index: -0.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0070
    Cell Significance Index: -0.0800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0070
    Cell Significance Index: -0.0800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0071
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0081
    Cell Significance Index: -0.0900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0087
    Cell Significance Index: -0.0800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0090
    Cell Significance Index: -0.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0101
    Cell Significance Index: -0.1200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0104
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0120
    Cell Significance Index: -0.1000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0148
    Cell Significance Index: -0.1200
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0187
    Cell Significance Index: -0.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD32A is a small nucleolar RNA, belonging to the C/D box class, which is known to be involved in various aspects of RNA processing, including ribosome biogenesis and RNA modification. The presence of this gene in a wide range of cell types, including pericytes, plasma cells, and cardiac endothelial cells, suggests a broader functional scope. Notably, SNORD32A has been identified as a significant component of the nucleolus, a key organelle responsible for ribosome synthesis and RNA processing. **Pathways and Functions:** The SNORD32A gene is intricately linked to several critical pathways, including nucleolus and RNA processing. As a small nucleolar RNA, SNORD32A plays a pivotal role in regulating ribosome biogenesis, a process essential for protein synthesis. Additionally, SNORD32A has been implicated in the regulation of RNA modification, including pseudouridylation and 2'-O-methylation, which are crucial for the stability and function of various RNA molecules. The expression of SNORD32A in cardiac endothelial cells and smooth muscle myoblasts suggests its involvement in cardiovascular development and maintenance. Furthermore, the presence of SNORD32A in pericytes and plasma cells implies its role in maintaining vascular health and immune function. The identification of SNORD32A in immature innate lymphoid cells underscores its potential involvement in the development and function of the innate immune system. **Clinical Significance:** The clinical significance of SNORD32A is an area of ongoing research, with potential implications for various diseases. Given its expression in cardiac endothelial cells and smooth muscle myoblasts, SNORD32A may play a role in cardiovascular disorders, such as atherosclerosis and heart failure. Additionally, the presence of SNORD32A in plasma cells and pericytes suggests its potential involvement in autoimmune diseases and vascular dysfunction. Moreover, the identification of SNORD32A in immature innate lymphoid cells highlights its potential role in the development of immune-related disorders, such as autoimmune diseases and allergies. Further studies are needed to fully elucidate the clinical significance of SNORD32A and its potential as a therapeutic target for various diseases. In conclusion, the SNORD32A gene is a complex and multifaceted molecule with far-reaching implications for our understanding of RNA processing, cellular homeostasis, and disease. Further research is necessary to fully elucidate the key characteristics, pathways, and functions of SNORD32A, as well as its clinical significance, paving the way for potential therapeutic applications in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.