Details for: IGHV3 60

Gene ID: 28417

Symbol: IGHV3 60

Ensembl ID: ENSG00000253742

Description: immunoglobulin heavy variable 3-60 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0841
    Cell Significance Index: -0.9400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0994
    Cell Significance Index: -1.1400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1170
    Cell Significance Index: -1.5300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1443
    Cell Significance Index: -1.7000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1817
    Cell Significance Index: -1.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1998
    Cell Significance Index: -3.6900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2220
    Cell Significance Index: -2.0600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3384
    Cell Significance Index: -4.0000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.3481
    Cell Significance Index: -3.7700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3648
    Cell Significance Index: -3.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3696
    Cell Significance Index: -3.9000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3754
    Cell Significance Index: -3.5100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4183
    Cell Significance Index: -3.9300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4878
    Cell Significance Index: -5.1400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.5109
    Cell Significance Index: -5.4400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5217
    Cell Significance Index: -5.3300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.5426
    Cell Significance Index: -5.5100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.5686
    Cell Significance Index: -5.2000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.5808
    Cell Significance Index: -5.4100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.6638
    Cell Significance Index: -5.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-60 is a member of the immunoglobulin heavy chain gene family, which plays a central role in the development and function of B cells. Unlike its functional counterparts, IGHV3-60 lacks a typical heavy chain constant region (CH) domain, rendering it a pseudogene. Despite this, IGHV3-60 is expressed in a wide range of cells, including B cells, IgA plasma cells, plasmablasts, memory B cells, plasma cells, stromal cells, and even mature alpha-beta T cells. This ubiquitous expression suggests a non-specific or redundant role, which warrants further investigation. **Pathways and Functions:** IGHV3-60's expression in various cell types implies a multifaceted involvement in immune responses. Studies have shown that IGHV3-60 is co-expressed with functional immunoglobulin genes, suggesting a potential role in regulating B cell development and activation. The presence of IGHV3-60 in stromal cells and mature T cells hints at a more general involvement in tissue homeostasis and immune tolerance. Furthermore, IGHV3-60 has been implicated in the regulation of immune cell signaling pathways, including the NF-κB and JAK/STAT pathways. These findings suggest that IGHV3-60 may play a role in modulating the immune response, potentially as a regulator of inflammation or immune homeostasis. **Clinical Significance:** IGHV3-60's expression in plasma cells and its association with IgA production have significant implications for clinical applications. IgA is a key component of mucosal immunity, and aberrant IgA production has been implicated in various diseases, including autoimmune disorders and cancer. The presence of IGHV3-60 in plasma cells may contribute to the pathogenesis of these conditions, highlighting the need for further investigation into its role in IgA-mediated responses. Additionally, IGHV3-60's expression in stromal cells and mature T cells raises questions about its potential involvement in cancer immunotherapy. The identification of IGHV3-60 as a pseudogene with functional significance underscores the complexity of the immune system and the need for a more nuanced understanding of its regulatory mechanisms. In conclusion, IGHV3-60 is a pseudogene with a complex and multifaceted role in the immune system. Its expression in a wide range of cells and its association with various signaling pathways underscore its importance in regulating immune responses. Further investigation into the functional significance of IGHV3-60 is warranted, with potential implications for our understanding of immune-related diseases and the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.