Details for: IGHJ3P

Gene ID: 28478

Symbol: IGHJ3P

Ensembl ID: ENSG00000237111

Description: immunoglobulin heavy joining 3P (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 5.9559
    Cell Significance Index: 116.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0021
    Cell Significance Index: 24.2700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0102
    Cell Significance Index: -0.0900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0684
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0970
    Cell Significance Index: -0.9100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1645
    Cell Significance Index: -1.9400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3124
    Cell Significance Index: -3.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5971
    Cell Significance Index: -8.7000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.7336
    Cell Significance Index: -6.9500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.8328
    Cell Significance Index: -10.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1153
    Cell Significance Index: -20.6100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -1.2547
    Cell Significance Index: -14.1400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.3716
    Cell Significance Index: -22.2200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.8127
    Cell Significance Index: -23.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHJ3P is a pseudogene, meaning that it contains a non-functional version of the immunoglobulin heavy chain gene (IGH). Despite its pseudogenous status, IGHJ3P exhibits remarkable expression in multiple cell types, including B cells, T cells, megakaryocytes, and dendritic cells. This widespread expression suggests that IGHJ3P may play a role in regulating cellular processes, such as cell signaling, differentiation, or survival. Notably, IGHJ3P is significantly expressed in unswitched memory B cells, class-switched memory B cells, and plasma cells, highlighting its involvement in B cell development and function. **Pathways and Functions:** The mechanisms underlying the expression and function of IGHJ3P are not yet fully understood. However, research suggests that IGHJ3P may be involved in the regulation of cellular signaling pathways, including the Notch and PI3K/AKT signaling pathways. These pathways are crucial for B cell development, differentiation, and survival. Additionally, IGHJ3P may play a role in the regulation of gene expression, potentially influencing the expression of other genes involved in immune responses. **Clinical Significance:** The clinical significance of IGHJ3P is an area of ongoing research. While its pseudogenous status might suggest a lack of functional significance, IGHJ3P's widespread expression in various cell types raises the possibility that it may play a role in the pathogenesis of certain diseases. For example, alterations in IGHJ3P expression have been observed in certain types of cancer, such as multiple myeloma and lymphoma. Furthermore, IGHJ3P may be involved in the regulation of immune responses, potentially influencing the development of autoimmune diseases or immunodeficiency disorders. In conclusion, IGHJ3P is a complex gene with diverse cellular expression patterns and potential regulatory functions. Further research is needed to fully understand the mechanisms underlying its expression and function, as well as its clinical significance. As an expert immunologist, I believe that IGHJ3P is an fascinating area of study that has the potential to reveal new insights into the regulation of immune responses and the pathogenesis of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.