Details for: TRAJ25

Gene ID: 28730

Symbol: TRAJ25

Ensembl ID: ENSG00000211864

Description: T cell receptor alpha joining 25 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0257
    Cell Significance Index: 0.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0139
    Cell Significance Index: 0.1700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.0020
    Cell Significance Index: 0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0033
    Cell Significance Index: -0.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0067
    Cell Significance Index: -0.1200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0085
    Cell Significance Index: -0.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0100
    Cell Significance Index: -0.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0126
    Cell Significance Index: -0.1500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0131
    Cell Significance Index: -0.1400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0131
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0156
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0165
    Cell Significance Index: -0.1700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0237
    Cell Significance Index: -0.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional gene:** TRAJ25 is a non-functional gene, meaning that it does not encode a protein with a known or predicted function. 2. **Wide expression:** TRAJ25 is expressed in a diverse range of cell types, including CD8-positive and CD4-positive T cells, B cells, innate lymphoid cells, retinal rod cells, and plasma cells. 3. **Lack of known function:** Despite its widespread expression, the function of TRAJ25 remains unknown, making it a fascinating gene to study. 4. **Evolutionary conservation:** TRAJ25 is conserved across species, suggesting that it has been maintained through evolution, possibly due to its widespread expression and potential functional significance. **Pathways and Functions:** While the exact function of TRAJ25 is unknown, several pathways and mechanisms have been proposed based on its expression and conservation: 1. **Gene regulation:** TRAJ25 may play a role in regulating gene expression, particularly in the context of immune system development and function. 2. **Cell signaling:** TRAJ25 may be involved in cell signaling pathways, potentially influencing cell proliferation, differentiation, and survival. 3. **Epigenetic regulation:** TRAJ25 may be involved in epigenetic regulation, influencing chromatin structure and gene expression. 4. **Non-coding RNA processing:** TRAJ25 may be involved in the processing of non-coding RNAs, such as microRNAs and small interfering RNAs. **Clinical Significance:** The clinical significance of TRAJ25 is still unclear, but its expression in various cell types and tissues suggests that it may play a role in disease pathogenesis: 1. **Autoimmune diseases:** TRAJ25 may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, by regulating immune system function. 2. **Cancer:** TRAJ25 may be involved in cancer development and progression, particularly in the context of immune system dysregulation. 3. **Neurological disorders:** TRAJ25 may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, by regulating gene expression and cell signaling pathways. In conclusion, TRAJ25 is a non-functional gene with a wide range of expression, suggesting that it may have functions beyond the realm of immune system regulation. Further research is needed to uncover the mechanisms and clinical significance of TRAJ25, but its discovery highlights the complexity and diversity of the human genome.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.