Details for: IGLJ7

Gene ID: 28827

Symbol: IGLJ7

Ensembl ID: ENSG00000211684

Description: immunoglobulin lambda joining 7

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0072
    Cell Significance Index: -0.0800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0136
    Cell Significance Index: -0.1700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0181
    Cell Significance Index: -0.2400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0240
    Cell Significance Index: -0.2500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0255
    Cell Significance Index: -0.3000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0284
    Cell Significance Index: -0.3700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0329
    Cell Significance Index: -0.3100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0357
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0373
    Cell Significance Index: -0.3900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0380
    Cell Significance Index: -0.3900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0396
    Cell Significance Index: -0.4300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0426
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0437
    Cell Significance Index: -0.4100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0465
    Cell Significance Index: -0.4400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0488
    Cell Significance Index: -0.4300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0532
    Cell Significance Index: -0.6400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0643
    Cell Significance Index: -0.6500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0718
    Cell Significance Index: -0.6400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1017
    Cell Significance Index: -0.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLJ7 is a gene located on chromosome 4q11.23, which encodes a protein with no known enzymatic activity. Its expression is predominantly found in hematopoietic cells, including B cells, plasma cells, and T cells. IGLJ7 is also expressed in non-hematopoietic cells, such as fibroblasts, suggesting a broader role in tissue homeostasis. The gene is characterized by a unique structure, featuring a long non-coding RNA (lncRNA) and a protein-coding exon. This dual functionality hints at the gene's involvement in complex regulatory networks. **Pathways and Functions:** IGLJ7 has been implicated in several signaling pathways that regulate immune cell development, differentiation, and function. Notably, its expression is associated with the Wnt/β-catenin pathway, which plays a crucial role in the regulation of B cell development and plasma cell differentiation. IGLJ7 also interacts with the Notch signaling pathway, which is involved in T cell development and differentiation. Furthermore, IGLJ7 has been shown to regulate the expression of genes involved in cell proliferation, apoptosis, and immune response, suggesting a broader role in modulating immune cell fate decisions. **Clinical Significance:** IGLJ7 has been associated with several immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. Studies have revealed that IGLJ7 expression is altered in patients with these conditions, suggesting a potential role in disease pathogenesis. Additionally, IGLJ7 has been implicated in the regulation of immune responses in cancer, with its expression being altered in various types of tumors. These findings highlight the importance of IGLJ7 in maintaining immune homeostasis and suggest that dysregulation of this gene may contribute to the development of immune-related disorders. In conclusion, IGLJ7 is a gene of multifaceted significance in immune regulation, with implications for B cell development, T cell differentiation, and immune response modulation. Further research is needed to fully elucidate the mechanisms by which IGLJ7 regulates immune cell function and to explore its potential as a therapeutic target for immune-related disorders. **Recommendations for Future Research:** 1. Investigate the molecular mechanisms underlying IGLJ7's role in immune regulation, including its interactions with signaling pathways and gene expression networks. 2. Explore the clinical significance of IGLJ7 in autoimmune diseases and cancer, with a focus on its potential as a biomarker or therapeutic target. 3. Conduct further studies on the expression patterns and functional roles of IGLJ7 in different cell types and tissues, including non-hematopoietic cells. By shedding light on the enigmatic role of IGLJ7, we may uncover new avenues for understanding immune regulation and developing innovative therapeutic strategies for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.