Gene OR8K1 - ENSG00000150261 | NCBI Gene ID: 390157

Details for: OR8K1

Gene ID: 390157

Symbol: OR8K1

Ensembl ID: ENSG00000150261

Description: olfactory receptor family 8 subfamily K member 1

Associated with

Expression and translocation of olfactory receptors
(R-HSA-9752946)
Olfactory signaling pathway
(R-HSA-381753)
Sensory perception
(R-HSA-9709957)
Detection of chemical stimulus involved in sensory perception of smell
(GO:0050911)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Odorant binding
(GO:0005549)
Olfactory receptor activity
(GO:0004984)
Plasma membrane
(GO:0005886)
Sensory perception of smell
(GO:0007608)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mononuclear cell (CL0000842)
Fold Change: 7.49
Marker Score: 2412
Cell Name: renal principal cell (CL0005009)
Fold Change: 3.13
Marker Score: 2409
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.69
Marker Score: 2412
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 2.47
Marker Score: 1969
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.25
Marker Score: 2385
Cell Name: brush cell (CL0002204)
Fold Change: 1.83
Marker Score: 1668
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.7
Marker Score: 2413
Cell Name: goblet cell (CL0000160)
Fold Change: 1.48
Marker Score: 9818
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 1.48
Marker Score: 2397
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.12
Marker Score: 2320
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.09
Marker Score: 6583
Cell Name: abnormal cell (CL0001061)
Fold Change: 1.08
Marker Score: 3222
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.02
Marker Score: 2398
Cell Name: absorptive cell (CL0000212)
Fold Change: 1
Marker Score: 30902
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2396.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.89
Marker Score: 2379
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.83
Marker Score: 4762.5
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.68
Marker Score: 2402.5

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**Key Characteristics:** OR8K1 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family, which is responsible for detecting odorant molecules in the air. The gene is characterized by its expression in various cell types, including those found in the kidney, intestine, and mononuclear cells. This widespread expression suggests that OR8K1 plays a critical role in the regulation of olfactory signaling pathways. Moreover, OR8K1 is involved in the detection of chemical stimuli, which is essential for the perception of smell. **Pathways and Functions:** OR8K1 is involved in several key pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell:** OR8K1 is responsible for detecting odorant molecules in the air, which triggers the activation of olfactory signaling pathways. 2. **Expression and translocation of olfactory receptors:** OR8K1 is involved in the regulation of olfactory receptor expression and translocation, which is essential for the proper functioning of olfactory signaling pathways. 3. **G protein-coupled receptor activity:** OR8K1 is a GPCR that activates G proteins upon binding to odorant molecules, leading to the activation of downstream signaling pathways. 4. **G protein-coupled receptor signaling pathway:** OR8K1 is involved in the regulation of G protein-coupled receptor signaling pathways, which are essential for the transmission of signals from olfactory receptors to the brain. **Clinical Significance:** OR8K1 has significant clinical implications in the context of olfactory perception and related disorders. Some of the potential clinical applications of OR8K1 include: 1. **Olfactory disorders:** OR8K1 may play a role in the development of olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological disorders:** OR8K1 may be involved in the regulation of olfactory signaling pathways in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer diagnosis:** OR8K1 may be used as a biomarker for the diagnosis of certain types of cancer, such as lung cancer and breast cancer. In conclusion, OR8K1 is a novel olfactory receptor that plays a critical role in the detection of chemical stimuli involved in sensory perception of smell. Its widespread expression in various cell types and involvement in key pathways suggest its significant clinical implications in the context of olfactory perception and related disorders. Further research is needed to fully elucidate the functions and significance of OR8K1.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Olfactory receptor 8K1

Genular Protein ID: 3694723709

Symbol: OR8K1_HUMAN

Name: Olfactory receptor 8K1

UniProtKB Accession Codes:

Q8NGG5 B9EJB1 Q6IFC3 Q96RC1

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

Length: 319
Mass: 36581
Checksum: 9CB4F7F94917E9D5
Sequence:

MNHVVKHNHT AVTKVTEFIL MGITDNPGLQ APLFGLFLII YLVTVIGNLG MVILTYLDSK 
LHTPMYFFLR HLSITDLGYS TVIAPKMLVN FIVHKNTISY NWYATQLAFF EIFIISELFI 
LSAMAYDRYV AICKPLLYVI IMAEKVLWVL VIVPYLYSTF VSLFLTIKLF KLSFCGSNII 
SYFYCDCIPL MSILCSDTNE LELIILIFSG CNLLFSLSIV LISYMFILVA ILRMNSRKGR 
YKAFSTCSSH LTVVIMFYGT LLFIYLQPKS SHTLAIDKMA SVFYTLLIPM LNPLIYSLRN 
KEVKDALKRT LTNRFKIPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.