Details for: MIR657

Gene ID: 724027

Symbol: MIR657

Ensembl ID: ENSG00000207736

Description: microRNA 657

Associated with

  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of interleukin-37 production
    (GO:0150138)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Regulation of inflammatory response
    (GO:0050727)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 5.07
    Marker Score: 2244
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 5.01
    Marker Score: 2389
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 3.95
    Marker Score: 2373
  • Cell Name: pericyte (CL0000669)
    Fold Change: 3.92
    Marker Score: 2288
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 2.47
    Marker Score: 1969
  • Cell Name: brush cell (CL0002204)
    Fold Change: 1.83
    Marker Score: 1668
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.48
    Marker Score: 9818
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.48
    Marker Score: 2397
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.09
    Marker Score: 6583
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.08
    Marker Score: 3222
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.04
    Marker Score: 1975
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1
    Marker Score: 2395
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1
    Marker Score: 30902
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 1999
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.89
    Marker Score: 2266
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4725
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.78
    Marker Score: 2408
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.32
    Marker Score: 1894
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.27
    Marker Score: 4148
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.07
    Marker Score: 2408

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Other Information

**Key Characteristics:** 1. **MicroRNA structure:** MIR657 is a 22-nucleotide long non-coding RNA that belongs to the microRNA family. 2. **Target gene regulation:** MIR657 targets various mRNAs involved in inflammation, cell proliferation, and immune responses, including interleukin-37, interleukin-6, tumor necrosis factor, and cell population proliferation regulators. 3. **Cell type specificity:** MIR657 is highly expressed in neuronal receptor cells, smooth muscle myoblasts, lymphoid lineage restricted progenitor cells, and neoplastic cells, indicating its role in specific tissue types. 4. **Pathway involvement:** MIR657 is involved in mirna-mediated post-transcriptional gene silencing, mrna base-pairing translational repressor activity, negative regulation of interleukin-37 production, positive regulation of cell population proliferation, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production, regulation of inflammatory response, and risc complex. **Pathways and Functions:** 1. **Inflammation regulation:** MIR657 negatively regulates interleukin-37 production, a cytokine involved in the resolution of inflammation, and positively regulates interleukin-6 and tumor necrosis factor production, which are pro-inflammatory cytokines. 2. **Cell proliferation regulation:** MIR657 positively regulates cell population proliferation, suggesting its role in promoting cell growth and division. 3. **Immune response regulation:** MIR657 is involved in the regulation of the inflammatory response, influencing the expression of genes involved in inflammation and immune responses. 4. **Risc complex involvement:** MIR657 interacts with the risc complex, a protein complex involved in the regulation of gene expression and the response to viral infections. **Clinical Significance:** The dysregulation of MIR657 has been implicated in various pathological conditions, including: 1. **Inflammation:** MIR657 dysregulation has been linked to inflammatory diseases, such as arthritis and inflammatory bowel disease. 2. **Cancer:** MIR657 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in cancer progression. 3. **Neurological disorders:** MIR657 dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, microRNA 657 is a critical regulator of inflammation, cell proliferation, and immune responses in various tissue types. Its dysregulation has been implicated in several pathological conditions, highlighting the importance of MIR657 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which MIR657 regulates gene expression and its role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.