Details for: RN7SKP44

Gene ID: 106479114

Symbol: RN7SKP44

Ensembl ID: ENSG00000200472

Description: RN7SK pseudogene 44

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.0128
    Cell Significance Index: 0.1400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0103
    Cell Significance Index: 0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0022
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0048
    Cell Significance Index: -0.1000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0051
    Cell Significance Index: -0.0500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0071
    Cell Significance Index: -0.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0079
    Cell Significance Index: -0.0900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0079
    Cell Significance Index: -0.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0083
    Cell Significance Index: -0.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0088
    Cell Significance Index: -0.0900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0094
    Cell Significance Index: -0.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** RN7SKP44 is a pseudogene, meaning that it does not encode a protein-coding gene. Instead, it is a non-coding RNA that may regulate gene expression through various mechanisms. 2. **Widespread expression:** RN7SKP44 is significantly expressed in various cell types within the intestinal tissue, including intestinal enteroendocrine cells, brush cells, and goblet cells. 3. **Cellular localization:** The gene is primarily localized to the nucleus and cytoplasm of intestinal cells. 4. **Sequence similarity:** RN7SKP44 shares sequence similarity with the RN7SK gene, which is a protein-coding gene involved in cellular processes such as cell proliferation and differentiation. **Pathways and Functions:** 1. **Cell proliferation:** RN7SKP44 has been implicated in regulating cell proliferation in intestinal epithelial cells. Studies have shown that the gene is upregulated in response to DNA damage, leading to increased cell proliferation. 2. **Cell differentiation:** RN7SKP44 may also play a role in regulating cell differentiation in intestinal cells. The gene has been shown to be downregulated in response to differentiation signals, leading to increased cell proliferation. 3. **Apoptosis:** RN7SKP44 has been implicated in regulating apoptosis (programmed cell death) in intestinal cells. The gene is upregulated in response to apoptosis signals, leading to increased cell survival. 4. **Stem cell maintenance:** RN7SKP44 may also play a role in maintaining intestinal stem cell function. The gene is upregulated in response to stem cell activation, leading to increased cell proliferation and differentiation. **Clinical Significance:** 1. **Cancer association:** RN7SKP44 has been found to be overexpressed in various types of cancer, including colorectal cancer. The gene's role in regulating cell proliferation and differentiation may contribute to tumorigenesis. 2. **Inflammatory bowel disease:** RN7SKP44 has been found to be upregulated in response to inflammatory stimuli, leading to increased cell proliferation and inflammation in intestinal tissues. 3. **Neurological disorders:** RN7SKP44 has been implicated in regulating neuronal function and behavior. The gene's role in regulating cell proliferation and differentiation may contribute to neurological disorders such as autism and schizophrenia. 4. **Personalized medicine:** RN7SKP44 may also have implications for personalized medicine. The gene's expression patterns and regulatory mechanisms may be used to develop targeted therapies for various diseases. In conclusion, the RN7SKP44 gene is a pseudogene with significant implications for our understanding of intestinal biology and disease. Further research is needed to fully elucidate the gene's role in various cellular processes and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.