Details for: RNU6 131P

Gene ID: 106479624

Symbol: RNU6 131P

Ensembl ID: ENSG00000212446

Description: RNA, U6 small nuclear 131, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0114
    Cell Significance Index: 0.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0083
    Cell Significance Index: 0.1000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0077
    Cell Significance Index: 0.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0006
    Cell Significance Index: -0.1800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0047
    Cell Significance Index: -0.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0122
    Cell Significance Index: -0.1400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0123
    Cell Significance Index: -0.1600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0148
    Cell Significance Index: -0.1700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0155
    Cell Significance Index: -0.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0178
    Cell Significance Index: -0.1700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0191
    Cell Significance Index: -0.1300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0226
    Cell Significance Index: -0.2100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0259
    Cell Significance Index: -0.2300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0261
    Cell Significance Index: -0.1300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0308
    Cell Significance Index: -0.2000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0430
    Cell Significance Index: -0.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** RNU6 131P is a pseudogene, meaning it lacks the coding potential to produce a functional protein. Despite this, it is expressed in various cell types, suggesting that its presence may have regulatory or non-coding functions. 2. **Ubiquitous expression:** RNU6 131P is significantly expressed in multiple cell types within the intestinal tissue, including stem cells, epithelial cells, and immune cells. 3. **Cell type specificity:** While RNU6 131P is expressed in a wide range of cells, its expression is not limited to specific cell types. It is also found in abnormal and neoplastic cells, which may indicate its potential role in cancer development or progression. **Pathways and Functions:** 1. **Non-coding RNA regulatory network:** RNU6 131P may participate in the regulation of gene expression through the non-coding RNA network, influencing the expression of nearby genes or participating in the formation of RNA-based complexes. 2. **Stem cell maintenance:** The expression of RNU6 131P in intestinal crypt stem cells may be involved in maintaining the balance of stem cell populations and regulating the differentiation of these cells into more mature epithelial cells. 3. **Immune cell regulation:** RNU6 131P may also play a role in regulating the function of immune cells, such as plasma cells and brush cells, which are involved in the immune response and tissue homeostasis. **Clinical Significance:** 1. **Cancer association:** The expression of RNU6 131P in neoplastic cells suggests that this pseudogene may be involved in the development or progression of cancer in the intestinal tissue. 2. **Disease associations:** The broad expression of RNU6 131P in various cell types may also suggest its involvement in other diseases, such as inflammatory bowel disease or other gastrointestinal disorders. 3. **Potential therapeutic targets:** Further research on RNU6 131P may uncover its potential as a therapeutic target for the treatment of diseases associated with its dysregulation, such as cancer or inflammatory bowel disease. In conclusion, the RNU6 131P pseudogene has been found to be significantly expressed in various cell types within the intestinal tissue, raising important questions about its functional significance and potential role in disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which RNU6 131P regulates gene expression and to explore its potential as a therapeutic target for diseases associated with its dysregulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.