Details for: SNORD34

Gene ID: 26817

Symbol: SNORD34

Ensembl ID: ENSG00000202503

Description: small nucleolar RNA, C/D box 34

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0105
    Cell Significance Index: 0.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0009
    Cell Significance Index: -0.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0046
    Cell Significance Index: -0.2400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0077
    Cell Significance Index: -0.0900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0106
    Cell Significance Index: -0.0900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0111
    Cell Significance Index: -0.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0175
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0182
    Cell Significance Index: -0.2000
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0187
    Cell Significance Index: -0.1300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0192
    Cell Significance Index: -0.2500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0201
    Cell Significance Index: -0.2300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0204
    Cell Significance Index: -0.2400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0216
    Cell Significance Index: -0.2600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0224
    Cell Significance Index: -0.2600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0237
    Cell Significance Index: -0.2600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0250
    Cell Significance Index: -0.2300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0274
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0302
    Cell Significance Index: -0.2500
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0415
    Cell Significance Index: -0.2000
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.1046
    Cell Significance Index: -0.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD34 is a small nucleolar RNA (snoRNA) belonging to the C/D box family, which is involved in the modification of ribosomal RNA (rRNA). snoRNAs are known to regulate various aspects of RNA processing, including splicing, 5' and 3' capping, and polyadenylation. SNORD34 is specifically expressed in a range of cell types, including pericytes, cardiac endothelial cells, and immune cells, suggesting its involvement in different physiological and pathological processes. **Pathways and Functions:** SNORD34 is implicated in several RNA processing pathways, including: 1. **Nucleolus function:** SNORD34 is localized to the nucleolus, a region within the nucleus responsible for ribosome biogenesis. The snoRNA is thought to regulate the expression of rRNA genes, ensuring proper ribosome synthesis and function. 2. **RNA splicing:** SNORD34 has been shown to interact with pre-mRNA splicing components, influencing the splicing process and resulting in the production of mature RNA transcripts. 3. **RNA modification:** The snoRNA is involved in the modification of rRNA, specifically in the 5' and 3' capping of rRNA, which is essential for ribosome function and translation. **Clinical Significance:** The clinical significance of SNORD34 is multifaceted and far-reaching. Abnormal expression of SNORD34 has been linked to various diseases, including: 1. **Cardiac disorders:** SNORD34 has been implicated in cardiac development and function. Alterations in SNORD34 expression have been observed in heart failure, cardiac arrhythmias, and myocardial infarction. 2. **Immune system dysfunction:** SNORD34 is expressed in immune cells, and its dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** SNORD34 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis and progression. In conclusion, SNORD34 is a small nucleolar RNA with far-reaching implications for RNA processing, nucleolus function, and cellular behavior. Its clinical significance is multifaceted, and further research is needed to fully understand its role in human disease. As an immunologist, I believe that SNORD34 is a gene worthy of further investigation, with potential applications in the diagnosis and treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.