Details for: IGHV8 51 1

Gene ID: 28343

Symbol: IGHV8 51 1

Ensembl ID: ENSG00000254167

Description: immunoglobulin heavy variable IGHV8-51-1 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4335
    Cell Significance Index: 5.4900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.1134
    Cell Significance Index: 1.1500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0652
    Cell Significance Index: 0.7700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0235
    Cell Significance Index: 0.3100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0033
    Cell Significance Index: 0.0400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0083
    Cell Significance Index: -0.0800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0143
    Cell Significance Index: -0.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0203
    Cell Significance Index: -0.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0265
    Cell Significance Index: -1.7100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0281
    Cell Significance Index: -0.3300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0317
    Cell Significance Index: -0.4000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0321
    Cell Significance Index: -0.4200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0396
    Cell Significance Index: -0.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0401
    Cell Significance Index: -0.5300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0447
    Cell Significance Index: -0.4800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0468
    Cell Significance Index: -0.5200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0488
    Cell Significance Index: -0.5800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0543
    Cell Significance Index: -0.5800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0553
    Cell Significance Index: -0.7200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0614
    Cell Significance Index: -0.6600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0769
    Cell Significance Index: -0.7200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1254
    Cell Significance Index: -1.3000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1728
    Cell Significance Index: -1.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV8-51-1 is a member of the IGHV gene family, which encodes the variable regions of the heavy chain of immunoglobulins. Unlike other IGHV genes, IGHV8-51-1 is non-functional, meaning it does not encode a functional antigen-binding site. Instead, this gene is thought to play a regulatory role in the development and maturation of lymphoid cells. IGHV8-51-1 is expressed in a range of lymphoid populations, including double-negative thymocytes, precursor B cells, and early lymphoid progenitors, suggesting its involvement in the early stages of lymphoid development. **Pathways and Functions:** IGHV8-51-1 is implicated in several key pathways, including antigen binding, extracellular region, immunoglobulin complex, immunoglobulin-mediated immune response, and plasma membrane. While the gene itself does not encode a functional antigen receptor, its expression is thought to influence the development and function of lymphoid cells through various mechanisms. For example, IGHV8-51-1 may regulate the expression of other genes involved in antigen recognition and immune response, or it may influence the binding of immunoglobulins to the plasma membrane, thereby modulating immune cell function. **Clinical Significance:** The clinical significance of IGHV8-51-1 is multifaceted. As a non-functional gene, IGHV8-51-1 does not directly contribute to the generation of functional antibodies. However, its expression in lymphoid progenitor and mature lymphocyte populations suggests that it may play a role in the regulation of lymphoid cell development and function. Furthermore, alterations in IGHV8-51-1 expression have been linked to various immune-related disorders, including autoimmune diseases and lymphoid malignancies. Therefore, further investigation into the mechanisms by which IGHV8-51-1 regulates lymphoid cell development and function is necessary to fully understand its clinical significance. In conclusion, the IGHV8-51-1 gene is a non-functional immunoglobulin variable region that plays a critical role in the regulation of lymphoid cell development and function. Its expression in various lymphoid populations and involvement in key pathways highlight its importance in the context of immune response and lymphoid development. Further research is necessary to fully elucidate the mechanisms by which IGHV8-51-1 regulates lymphoid cell development and function, and to explore its clinical significance in the context of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.