Details for: MIR92A1

Gene ID: 407048

Symbol: MIR92A1

Ensembl ID: ENSG00000283705

Description: microRNA 92a-1

Associated with

  • Blood vessel diameter maintenance
    (GO:0097746)
  • Cellular response to fatty acid
    (GO:0071398)
  • Cellular response to low-density lipoprotein particle stimulus
    (GO:0071404)
  • Cellular stress response to acid chemical
    (GO:0097533)
  • Cytoplasm
    (GO:0005737)
  • Extracellular space
    (GO:0005615)
  • Extracellular vesicle
    (GO:1903561)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of blood vessel endothelial cell migration
    (GO:0043537)
  • Negative regulation of collagen biosynthetic process
    (GO:0032966)
  • Negative regulation of endothelial cell-matrix adhesion via fibronectin
    (GO:1904905)
  • Negative regulation of endothelial cell proliferation
    (GO:0001937)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
    (GO:1903751)
  • Negative regulation of nitric oxide biosynthetic process
    (GO:0045019)
  • Negative regulation of sprouting angiogenesis
    (GO:1903671)
  • Positive regulation of acute inflammatory response
    (GO:0002675)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of endothelial cell activation
    (GO:1904989)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of jun kinase activity
    (GO:0043507)
  • Positive regulation of leukocyte adhesion to arterial endothelial cell
    (GO:1904999)
  • Positive regulation of leukocyte adhesion to vascular endothelial cell
    (GO:1904996)
  • Positive regulation of metalloendopeptidase activity
    (GO:1904685)
  • Positive regulation of monocyte chemotactic protein-1 production
    (GO:0071639)
  • Positive regulation of programmed necrotic cell death
    (GO:0062100)
  • Positive regulation of sprouting angiogenesis
    (GO:1903672)
  • Regulation of heart contraction
    (GO:0008016)
  • Risc complex
    (GO:0016442)
  • Vascular endothelial cell response to fluid shear stress
    (GO:0097699)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.0057
    Cell Significance Index: 0.0600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0003
    Cell Significance Index: -0.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0016
    Cell Significance Index: -0.0800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0045
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0060
    Cell Significance Index: -0.0800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0064
    Cell Significance Index: -0.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0069
    Cell Significance Index: -0.0800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0070
    Cell Significance Index: -0.0800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0079
    Cell Significance Index: -0.0900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0083
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0106
    Cell Significance Index: -0.0900
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0125
    Cell Significance Index: -0.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MIR92A1 is a 22-nucleotide long non-coding RNA that belongs to the miR-92 family. It is highly conserved across species, suggesting its essential role in regulating cellular processes. MIR92A1 has been shown to bind to the 3'-untranslated region (3'-UTR) of target mRNAs, leading to their degradation or inhibition of translation. This microRNA has been implicated in regulating angiogenesis, inflammation, and cell proliferation, making it a valuable target for therapeutic interventions. **Pathways and Functions** MIR92A1 has been implicated in various biological pathways, including: 1. **Angiogenesis**: MIR92A1 negatively regulates angiogenesis, a process crucial for tumor growth and metastasis. By inhibiting the expression of pro-angiogenic genes, MIR92A1 can prevent the formation of new blood vessels. 2. **Inflammation**: MIR92A1 has been shown to regulate inflammatory responses by modulating the expression of inflammatory genes. Its positive regulation of inflammatory responses can contribute to tissue damage and disease progression. 3. **Cell Proliferation**: MIR92A1 can regulate cell proliferation by modulating the expression of cell cycle-related genes. Its negative regulation of cell proliferation can prevent tumor growth and metastasis. 4. **Endothelial Cell Function**: MIR92A1 has been implicated in regulating endothelial cell function, including cell migration, adhesion, and contraction. **Clinical Significance** MIR92A1 has been implicated in various diseases, including: 1. **Cancer**: MIR92A1 has been shown to be downregulated in various types of cancer, including breast, lung, and colon cancer. Its dysregulation can contribute to tumor progression and metastasis. 2. **Cardiovascular Disease**: MIR92A1 has been implicated in regulating cardiovascular function, including blood pressure regulation and vascular tone. 3. **Neurological Disorders**: MIR92A1 has been shown to regulate neuronal function and synaptic plasticity, making it a potential target for the treatment of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, MIR92A1 is a complex and multifaceted microRNA that plays a crucial role in regulating various cellular processes, including angiogenesis, inflammation, and cell proliferation. Its dysregulation can contribute to disease progression, making it a valuable target for therapeutic interventions. Further research is needed to fully understand the mechanisms of MIR92A1 and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.