Details for: OR11H12

Gene ID: 440153

Symbol: OR11H12

Ensembl ID: ENSG00000257115

Description: olfactory receptor family 11 subfamily H member 12

Associated with

  • Detection of chemical stimulus involved in sensory perception of smell
    (GO:0050911)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Olfactory receptor activity
    (GO:0004984)
  • Plasma membrane
    (GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.54
    Marker Score: 10230.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3638
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.19
    Marker Score: 1263
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.15
    Marker Score: 6995.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.12
    Marker Score: 1241
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.08
    Marker Score: 1265
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.03
    Marker Score: 825
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.02
    Marker Score: 31736
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.98
    Marker Score: 1269
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5121
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.82
    Marker Score: 745
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.61
    Marker Score: 1261
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.47
    Marker Score: 1265
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.37
    Marker Score: 1269
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.02
    Marker Score: 1269

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Other Information

**Key Characteristics:** OR11H12 is a member of the olfactory receptor family, which is a group of G protein-coupled receptors (GPCRs) that are responsible for detecting odorant molecules in the air we breathe. These receptors are expressed in the olfactory epithelium, a specialized tissue in the nasal cavity that is responsible for detecting chemical stimuli. OR11H12 is specifically expressed in various cell types, including goblet cells, macrophages, and intestinal enteroendocrine cells, which suggests that it may play a role in regulating multiple physiological processes beyond olfactory perception. **Pathways and Functions:** OR11H12 is involved in the detection of chemical stimuli involved in sensory perception of smell, as well as other physiological processes. The gene is part of the G protein-coupled receptor signaling pathway, which is a complex network of signaling molecules that transmit signals from the cell surface to the interior of the cell. When a chemical stimulus binds to OR11H12, it triggers a signaling cascade that activates G proteins, which in turn activate downstream effectors that regulate various cellular processes. The specific functions of OR11H12 are not yet fully understood, but research suggests that it may play a role in regulating inflammation, immune responses, and gastrointestinal function. For example, OR11H12 has been shown to be expressed in macrophages, a type of immune cell that plays a key role in detecting and eliminating pathogens. OR11H12 may also be involved in regulating the gut microbiome, which is the collection of microorganisms that live in the gastrointestinal tract. **Clinical Significance:** OR11H12 has significant clinical implications, particularly in the fields of olfaction and immunology. Research has shown that OR11H12 is involved in the regulation of olfactory perception, and mutations in the OR11H12 gene have been associated with olfactory dysfunction and other neurological disorders. In addition, OR11H12 may have implications for the treatment of inflammatory and immune-related disorders, such as asthma and autoimmune diseases. For example, research has shown that OR11H12 is expressed in airway epithelial cells, which are involved in the regulation of inflammation and immune responses. Furthermore, OR11H12 may also have implications for the treatment of gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome. Research has shown that OR11H12 is expressed in intestinal enteroendocrine cells, which play a key role in regulating gut motility and secretion. In conclusion, OR11H12 is a complex gene that plays a crucial role in olfactory perception and other physiological processes. Further research is needed to fully understand the functions of OR11H12 and its clinical significance, but it is clear that this gene has the potential to revolutionize our understanding of olfaction and immunology.

Genular Protein ID: 1780588706

Symbol: O11HC_HUMAN

Name: Olfactory receptor 11H12

UniProtKB Accession Codes:

B2RN74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 326
  • Mass: 36530
  • Checksum: F616037020AB0550
  • Sequence:
    • MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFTCEWTIQI FLFSLFTTTY ALTITGNGAI 
AFVLWCDWRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF LSEKKNISFA GCFLQFYFFF 
SLGTSECLLL TVMAFDQYLA ICRPLLYPNI MTGHLCAKLV ILCWVCGFLW FLIPIVLISQ 
MPFCGPNIID HVVCDPGPRF ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV 
LGMPSSTGRH KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF 
NPLIYSLQNK EIKAALRKVL GSSNII

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.