Details for: DIABLO

Gene ID: 56616

Symbol: DIABLO

Ensembl ID: ENSG00000184047

Description: diablo IAP-binding mitochondrial protein

Associated with

Other Information

Genular Protein ID: 3895163525

Symbol: DBLOH_HUMAN

Name: Diablo IAP-binding mitochondrial protein, cleaved form

UniProtKB Accession Codes:

Q9NR28 B2RDQ0 Q6W3F3 Q96LV0 Q9BT11 Q9HAV6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 9 EMDB 4 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 16 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 6 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 3 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10929711

Title: Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.

PubMed ID: 10929711

DOI: 10.1016/s0092-8674(00)00008-8

PubMed ID: 10950947

Title: Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.

PubMed ID: 10950947

DOI: 10.1074/jbc.c000533200

PubMed ID: 14523016

Title: Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein.

PubMed ID: 14523016

DOI: 10.1074/jbc.m308036200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15200957

Title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

PubMed ID: 15200957

DOI: 10.1016/j.molcel.2004.05.018

PubMed ID: 16729033

Title: Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway.

PubMed ID: 16729033

DOI: 10.1038/sj.cdd.4401959

PubMed ID: 21695558

Title: ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists.

PubMed ID: 21695558

DOI: 10.1007/s10495-011-0622-0

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21536684

Title: Survivin monomer plays an essential role in apoptosis regulation.

PubMed ID: 21536684

DOI: 10.1074/jbc.m111.237586

PubMed ID: 23479728

Title: Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.

PubMed ID: 23479728

DOI: 10.1074/jbc.m112.436113

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28288130

Title: PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

PubMed ID: 28288130

DOI: 10.1038/ncb3488

PubMed ID: 10972280

Title: Structural and biochemical basis of apoptotic activation by Smac/DIABLO.

PubMed ID: 10972280

DOI: 10.1038/35022514

PubMed ID: 11140637

Title: Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.

PubMed ID: 11140637

DOI: 10.1038/35050006

PubMed ID: 19153467

Title: The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.

PubMed ID: 19153467

DOI: 10.1107/s0907444908039243

PubMed ID: 21722859

Title: Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64.

PubMed ID: 21722859

DOI: 10.1016/j.ajhg.2011.05.027

Sequence Information:

  • Length: 239
  • Mass: 27131
  • Checksum: 70C2AE0DC654D031
  • Sequence:
    • MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA 
QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL 
LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS 
ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED

Genular Protein ID: 3844006336

Symbol: A0A024RBT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024RBT2 A0A024RBQ1

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 166
  • Mass: 18919
  • Checksum: 0D00E3F98BAAE71E
  • Sequence:
    • MRRAVSLVTD STSTFLSQTT YALIEAITEY TKAVYTLTSL YRQYTSLLGK MNSEEEDEVW 
QVIIGARAEM TSKHQEYLKL ETTWMTAVGL SEMAAEAAYQ TGADQASITA RNHIQLVKLQ 
VEEVHQLSRK AETKLAEAQI EELRQKTQEE GEERAESEQE AYLRED

Genular Protein ID: 1993431731

Symbol: K7X1S0_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7X1S0

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 142
  • Mass: 16314
  • Checksum: 3799FFEBD82DED75
  • Sequence:
    • MKSDFYFQAV YTLTSLYRQY TSLLGKMNSE EEDEVWQVII GARAEMTSKH QEYLKLETTW 
MTAVGLSEMA AEAAYQTGAD QASITARNHI QLVKLQVEEV HQLSRKAETK LAEAQIEELR 
QKTQGEGEER AESEQEAYLR ED

Genular Protein ID: 1576175559

Symbol: A0A0S2Z5P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z5P6

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 1 SAM 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 195
  • Mass: 22284
  • Checksum: B344087CF2A87C05
  • Sequence:
    • MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA 
QAVYTLTSLY RQYTSLLGKM NSEEEDEVWQ VIIGARAEMT SKHQEYLKLE TTWMTAVGLS 
EMAAEAAYQT GADQASITAR NHIQLVKLQV EEVHQLSRKA ETKLAEAQIE ELRQKTQEEG 
EERAESEQEA YLRED

Genular Protein ID: 3439419326

Symbol: Q502X2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q502X2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 3 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 186
  • Mass: 21233
  • Checksum: FF567F7827AB6108
  • Sequence:
    • MKSDFYFQKS EPHSLSSEAL MRRAVSLVTD STSTFLSQTT YALIEAITEY TKAVYTLTSL 
YRQYTSLLGK MNSEEEDEVW QVIIGARAEM TSKHQEYLKL ETTWMTAVGL SEMAAEAAYQ 
TGADQASITA RNHIQLVKLQ VEEVHQLSRK AETKLAEAQI EELRQKTQEE GEERAESEQE 
AYLRED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.