Details for: LINC01101

Gene ID: 84931

Symbol: LINC01101

Ensembl ID: ENSG00000280409

Description: long intergenic non-protein coding RNA 1101

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.0490
    Cell Significance Index: 11.0700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.4726
    Cell Significance Index: 6.5400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.4282
    Cell Significance Index: 5.9400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0945
    Cell Significance Index: 1.3100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0102
    Cell Significance Index: -0.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0209
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0366
    Cell Significance Index: -0.4500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0791
    Cell Significance Index: -0.7500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0804
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0820
    Cell Significance Index: -0.7700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0847
    Cell Significance Index: -0.7700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0909
    Cell Significance Index: -0.8900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1091
    Cell Significance Index: -1.1300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1138
    Cell Significance Index: -0.9400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1153
    Cell Significance Index: -0.7500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1163
    Cell Significance Index: -0.6900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1210
    Cell Significance Index: -0.7600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1296
    Cell Significance Index: -1.1900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1303
    Cell Significance Index: -1.4200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1305
    Cell Significance Index: -1.3700
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.1410
    Cell Significance Index: -1.4000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1443
    Cell Significance Index: -1.3500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.6027
    Cell Significance Index: -5.9500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.6139
    Cell Significance Index: -6.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC01101 is a lincRNA, a class of non-coding RNAs that do not encode proteins but regulate gene expression through various mechanisms. Its expression is tissue-specific, with significant levels detected in epithelial cells, neuronal receptor cells, and immune cells. Notably, LINC01101 is upregulated in various inflammatory and immune-related conditions, including cancer, autoimmune diseases, and infectious diseases. This suggests a potential role as a biomarker for disease diagnosis and monitoring. **Pathways and Functions:** Recent studies have elucidated the molecular pathways through which LINC01101 exerts its functions. These include: 1. **Immune cell regulation:** LINC01101 modulates the expression of immune-related genes, influencing the development, function, and differentiation of immune cells, such as T cells and B cells. 2. **Stromal cell regulation:** LINC01101 interacts with stromal cells, influencing their function and phenotype, which in turn affects the tumor microenvironment and immune cell infiltration. 3. **Tissue remodeling:** LINC01101 regulates the expression of genes involved in tissue remodeling, including those involved in fibrosis, inflammation, and cell proliferation. 4. **Epigenetic regulation:** LINC01101 interacts with epigenetic regulators, influencing chromatin structure and gene expression. **Clinical Significance:** The discovery of LINC01101's role in immune regulation and disease has significant implications for the diagnosis, treatment, and prevention of various immune-related disorders. Some potential applications include: 1. **Cancer immunotherapy:** LINC01101 may serve as a biomarker for identifying patients who would benefit from cancer immunotherapy. 2. **Autoimmune disease treatment:** LINC01101 may be a potential target for therapies aimed at modulating the immune system in autoimmune diseases. 3. **Infectious disease prevention:** LINC01101 may play a role in the development of novel vaccines and treatments for infectious diseases. 4. **Regenerative medicine:** LINC01101 may be involved in tissue remodeling and repair, making it a potential target for regenerative therapies. In conclusion, LINC01101 is a complex non-protein coding RNA that plays a multifaceted role in immune regulation and disease. Its expression profile, molecular mechanisms, and clinical significance highlight its potential as a valuable tool for understanding the intricacies of the immune system and developing novel therapies for various immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.