Details for: FOXO1B

Gene ID: 2311

Symbol: FOXO1B

Ensembl ID: ENSG00000214295

Description: forkhead box O1B (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.0202
    Cell Significance Index: 0.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0197
    Cell Significance Index: 0.5300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.0174
    Cell Significance Index: 0.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0132
    Cell Significance Index: 0.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0101
    Cell Significance Index: 0.2900
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0040
    Cell Significance Index: -0.0700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0062
    Cell Significance Index: -0.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0067
    Cell Significance Index: -0.0900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0080
    Cell Significance Index: -0.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0091
    Cell Significance Index: -0.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0095
    Cell Significance Index: -0.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0108
    Cell Significance Index: -0.2200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0168
    Cell Significance Index: -0.1100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0219
    Cell Significance Index: -0.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0311
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** FOXO1B is a pseudogene, meaning it lacks a functional coding sequence, yet it is still expressed in various cell types, suggesting its potential role in regulating gene expression and cellular processes. 2. **Widespread expression:** FOXO1B is significantly expressed in endothelial cells, fibroblasts, mesenchymal stem cells, T cells, and neurons, indicating its involvement in multiple cellular contexts. 3. **Conserved sequence:** Despite being a pseudogene, FOXO1B shares a high degree of sequence conservation with its functional counterpart, FOXO1, suggesting that it may have evolved to regulate similar cellular processes. **Pathways and Functions:** 1. **FOXO transcriptional network:** FOXO1B is part of the FOXO transcriptional network, which regulates the expression of genes involved in cell growth, differentiation, and survival. FOXO1B may modulate this network to influence cellular homeostasis and immune responses. 2. **Apoptosis and cell survival:** FOXO1B has been shown to regulate apoptosis and cell survival pathways, influencing the fate of cells in response to stress, injury, or inflammation. 3. **Immune cell function:** FOXO1B is expressed in T cells, where it may regulate T cell development, differentiation, and function, including cytokine production and cell-mediated immunity. 4. **Inflammation and immune regulation:** FOXO1B has been implicated in the regulation of inflammatory responses, modulating the expression of pro-inflammatory and anti-inflammatory genes. **Clinical Significance:** 1. **Immunological disorders:** Alterations in FOXO1B expression or function have been linked to immunological disorders, such as autoimmune diseases, cancer, and infectious diseases. 2. **Cancer therapy:** FOXO1B has been identified as a potential target for cancer therapy, as its dysregulation has been implicated in tumorigenesis and cancer progression. 3. **Neurological disorders:** FOXO1B has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to neuronal loss and degeneration. 4. **Immunomodulation:** FOXO1B may serve as a therapeutic target for immunomodulation, as its dysregulation has been linked to immune dysfunction and disease. In conclusion, the FOXO1B gene, despite being a pseudogene, has been shown to play a significant role in regulating immune responses, inflammation, and cellular homeostasis. Further research is necessary to elucidate the mechanisms by which FOXO1B influences cellular processes and to explore its clinical significance in the context of immunological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.