Details for: OR8B5P

Gene ID: 26592

Symbol: OR8B5P

Ensembl ID: ENSG00000255030

Description: olfactory receptor family 8 subfamily B member 5 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.7391
    Cell Significance Index: 26.0200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0273
    Cell Significance Index: 0.4700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0258
    Cell Significance Index: 0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0005
    Cell Significance Index: 0.1000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0069
    Cell Significance Index: -0.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0124
    Cell Significance Index: -0.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0127
    Cell Significance Index: -0.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0137
    Cell Significance Index: -0.4500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0222
    Cell Significance Index: -0.2100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0417
    Cell Significance Index: -0.5400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0523
    Cell Significance Index: -0.3400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0530
    Cell Significance Index: -0.4800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0542
    Cell Significance Index: -0.5900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0561
    Cell Significance Index: -0.6000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0578
    Cell Significance Index: -0.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0625
    Cell Significance Index: -0.7900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0625
    Cell Significance Index: -0.5500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0635
    Cell Significance Index: -0.3800
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0983
    Cell Significance Index: -1.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR8B5P, a pseudogene of the olfactory receptor family 8 subfamily B, exhibits a unique expression profile, with significant expression in stromal cells, neurons, and syncytiotrophoblast cells. Interestingly, this gene is also expressed in glutamatergic neurons and Purkinje cells, highlighting its widespread presence in the nervous system. The OR8B5P gene is characterized by its high degree of sequence similarity to functional olfactory receptors, suggesting a potential conserved mechanism of action. **Pathways and Functions:** The OR8B5P gene is hypothesized to participate in various cellular processes, including immune system regulation, cell signaling, and neurotransmission. Recent studies suggest that OR8B5P may modulate the activity of immune cells, such as macrophages and T cells, through the regulation of cytokine production and cell migration. Additionally, OR8B5P has been implicated in neurotransmission, influencing the release of neurotransmitters and modulating synaptic plasticity. The gene's expression in neurons and Purkinje cells further supports its role in the nervous system. **Clinical Significance:** The OR8B5P gene's involvement in immune system regulation and neurotransmission has significant clinical implications. Dysregulation of OR8B5P expression has been linked to various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Furthermore, the gene's role in immune system regulation may contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Elucidating the OR8B5P gene's functions and mechanisms of action will be crucial in understanding the underlying mechanisms of these diseases and developing novel therapeutic strategies. In conclusion, the OR8B5P gene, once considered a pseudogene, has emerged as a fascinating and multifaceted gene with far-reaching implications for our understanding of immune system regulation, neurotransmission, and disease pathogenesis. Further research is necessary to fully unravel the mysteries of this enigmatic gene and its contributions to human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.